Maybe berberine is the answer glucose induced lethargy. (or metformin or other glucose disposal agent. I wonder how ALA would do? One must just find the right dose.
Also...
It lowers cholesterol and may reduce your risk of heart disease
Heart disease is currently the leading cause of death around the globe (
17Trusted Source).
Many factors that can be measured in the blood are associated with an increased risk of
heart disease.
As it turns out, berberine has been shown to improve many of these factors.
According to a review of 16 studies, it could help (
18Trusted Source):
- lower total cholesterol
- lower LDL (bad) cholesterol
- lower blood triglycerides
- increase HDL (good) cholesterol
It has also been shown to lower apolipoprotein B by 13-15% in some older studies, which is an important risk factor for heart disease (
19Trusted Source,
20Trusted Source).
According to some research, berberine works by inhibiting an enzyme called PCSK9. This leads to more
LDL cholesterol being removed from the bloodstream (
21Trusted Source).
Keep in mind that diabetes, high blood sugar levels, and obesity are also major risk factors for heart disease, all of which seem to be improved with this supplement (
7Trusted Source).
Given the beneficial effects on all these risk factors, it seems likely that berberine could reduce the risk of heart disease, though more research is needed.