Do the Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, And Quality of Life Persist Six Months after Treatment in Intermediate-Frail and Frail Elderly Men?
Matthew D. L. O'Connell, Stephen A. Roberts, Upendram Srinivas-Shankar, Abdelouahid Tajar, Martin J. Connolly, Judith E. Adams, Jackie A. Oldham and Frederick C. W. Wu
- Author Affiliations
Andrology Research Unit, Developmental & Regenerative Biomedicine Research Group (M.D.L.O., U.S.-S., F.C.W.W.), Manchester Academic Health Science Centre, Manchester Royal Infirmary, The University of Manchester, Manchester, United Kingdom M13 9WL; Health Sciences Methodology (S.A.R.), Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom M13 9PL; Arthritis Research UK Epidemiology Unit (A.T.), Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom M13 9PT; Freemasons' Department of Geriatric Medicine (M.J.C.), University of Auckland, 1142 Auckland, New Zealand; Clinical Radiology, Imaging Science, and Biomedical Engineering (J.E.A.), Manchester Academic Health Science Centre, The University of Manchester, United Kingdom M13 6PT; Centre for Rehabilitation Science (J.A.O.), The University of Manchester, United Kingdom M13 9WL; and St Helens and Knowsley Teaching Hospitals NHS Trust (U.S.-S.), St Helens, United Kingdom WA9 3DA
Address all correspondence and requests for reprints to: Professor Frederick C.W. Wu, Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL. E-mail:
[email protected].
Abstract
Context:Short-term testosterone (T) treatment in frail elderly men improves muscle mass and strength. It is unclear whether these effects can be maintained post treatment.
Objective:To assess the durability of androgen effects in frail men.
Design and Setting:Single center, randomized, double-blind, placebo-controlled trial to investigate the effects of 6 months T (25–75 mg daily) on muscle strength, body composition, physical function, and quality of life (QoL). Participants were assessed at the end of treatment (6 months) and 6 months after treatment cessation (12 months).
Participants:274 intermediate-frail and frail elderly men aged 65–90 years with low T levels.
Results:Mean T increased from 11.1 (3.1) nmol/liter at baseline to 18.4 (3.5) nmol/liter at 6 months, then declined to 10.5 (3.7) nmol/L at 12 months, in the T-treated group. Isometric knee extension peak torque increased in the T-treated group compared with placebo to give an adjusted mean difference (95% CI) between groups of 8.1 (−0.2 to 16.5) Nm at 6 months. Lean mass increased in the T-treated group giving a difference between groups of 1.2 (0.8 to 1.7) kg at 6 months. Somatic and sexual symptoms improved during treatment. None of these differences between groups remained at 12 months. Prostate specific antigen (PSA) levels and haematocrit increased slightly during treatment but returned to baseline by 12 months.
Conclusion:The effects of 6-month T treatment on muscle strength, lean mass, and QoL in frail men are not maintained at 6 months post treatment.
Do the Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, And Quality of Life Persist Six Months after Treatment in Intermediate-Frail and Frail Elderly Men?