I've personally never seen the need to dose legit mt2 above 250mcgs. Hell, after a couple weeks at that dose, I was pulling back to eod because I was getting too dark, too fast. As others have stated, the freckling can be a result of dosing too high..and often will secede once administration of the pep is discontinued..but that is not always the case. It is very common for the darkening freckles and/or mole enlargement to be permanent.