You are smart. The dangers associated with DNP were known in the 1930's when the FDA removed it from the market, but not before thousands were harmed. It's unfortunate that there are still some who advocate that it can be used safely. For some, that might be true but its unpredictability offers NO guarantees you'll be one of them.
CBS
The following abstract is from a study on DNP's history that was posted on Meso by Dr Jim.
Abstract
In the early 1930s, the industrial chemical dinitrophenol found widespread favor as a weight-loss drug, due principally to the work of Maurice Tainter, a clinical pharmacologist from Stanford University.
Unfortunately the compound’s therapeutic index was razor thin and it was not until thousands of people suffered irreversible harm that mainstream physicians realized that dinitrophenol’s risks outweighed its benefits and abandoned its use. Yet, it took passage of the Food, Drug, and Cosmetic Act in 1938 before federal regulators had the ability to stop patent medicine men from selling dinitrophenol to Americans lured by the promise of a drug that would safely melt one’s fat away.
Cyril MacBryde, a physiologist from Washington University School of Medicine, reported ‘‘alarming functional changes’’ indicative of liver, heart, and muscle toxicity in his obese patients treated with small doses of dinitrophenol (MacBryde and Taussig, 1935).
But some physicians continued to believe that the drug was a reasonable therapeutic option for obese patients recalcitrant to dietary intervention when used in the properdose and under the care of a knowledgeable physician.
Even this position, however, became untenable when young women taking therapeutic doses of dinitrophenol under the supervision of physicians started going blind (Horner et al., 1935). If the estimate of one San Francisco ophthalmologist is accurate,
during a two and a half year span, as many as 2500 Americans may have lost their sight due to what became known as ‘‘dinitrophenol cataracts’’ (Horner, 1936).
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