Bigtex
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- Aug 14, 2012
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Like ALL hormone optimization, we are not just trying to bring our hormones level up to age norms, we are tryin to bring them up to what a young man would have.
Here is how much GH is normally produced by age groups:
Young adult men (20s): about 0.4 – 1.0 mg (~1–3 IU) per 24 hours
Middle-aged men (40s–50s): drops to around 0.2 – 0.4 mg (~0.5–1 IU) per 24 hours
Older men (60+): often <0.2 mg/day
Ages 21-30: Normal levels can range from 500-1000 ng/ml.
Ages 30-40: Levels may decline by 10-15% compared to younger adults. (50-150ng/mL)
Ages 40-50: Continued decline in HGH levels 10-15% per decade
Ages 50 and above: HGH levels may be significantly lower due to aging and other factors.
So if you are truly optimizing your specific hormone levels you need to not only optimize GH but IGF-1 levels. I tested last about 2 hours after a sub -q injection of 1.5iu and my GH was 2.9ng/mL (range < or = 7.ng/mL) and IGF-1 was at 163 ng/mL. So for my age IGF-1 needs to be brought up to optimal ranges (41-279 ng/mL). With 1.5iu/d I am on I am well within optimal ranges for both GH and IGF-1. Could I go 2iu? Probably, but I noticed side effects going up. Since guys my age only produce <0.2mg/d, 1.5iu puts me up to ~2iu/d. Very much in an optimal range for a 20 year old as seen in the graphs below. Remember a hormonal imbalance happens when you have too much or too little of one or more hormones. Optimization aims to balance your hormone levels to support various physiological functions, particularly those related to growth, metabolism, tissue repair, and aging.
So if your goal in using HGH is for life extension and anti-aging, 1.5 - 2iu/d is not too much at all. Now you guys going 4+ which is obviously supraphysiologic doses, your goal is most likely not HRT. Nothing wrong with that, but as you see most middle age men produce <1iu/d and those older than 60 produce<0.5
Feeling better is what it all about @jipped genes !!
In general:
Endogenous GH (your own production):
Normally, GH secretion is pulsatile, with the biggest pulses at night during deep sleep. High blood glucose and high insulin (from eating carbs, especially sugars/starches) suppress those pulses. That’s why people say “don’t eat carbs before bed if you want natural GH release.”
Exogenous rHGH (injected):
When you inject rHGH, you are bypassing your pituitary’s secretion entirely. The hormone is already in circulation, so insulin/glucose doesn’t “shut it off” or prevent it from working. It may however, limit lipolysis to some extent.
Remember lots of bodybuilders use 2–4 IU of rHGH ~1.5 hour pre-workout and fast-acting insulin (like Humalog) at 5–10 IU, 30 minutes pre-workout, followed by a carb-heavy intra-workout drink. In this case, rHGH starts mobilizing fats and raising IGF-1, then insulin kicks in to shuttle nutrients into muscles without fully blunting rHGH’s fat-burning phase. So the rHGH reaches it peak in ~2hours and the insulin peaks from 30-90 minutes. This gives rHGH time to do what it does promoting fat breakdown (lipolysis) and insulin-like growth factor-1 (IGF-1) stimulation. Once the insulin peaks and the carbs enter the blood, the two work synergistically which in turn drives glucose and amino acids into muscle cells, enhancing protein synthesis and glycogen storage, which complements rHGH’s IGF-1-mediated muscle growth effects. In this case, the transient insulin spike from carbs doesn’t at all negate its longer-term anabolic actions. So outside of exercise, consuming carbs shortly after an rHGH injection could reduce its effectiveness by raising insulin, which might inhibit lipolysis. But over all, because of rHGH’s exogenous nature makes it less sensitive to insulin’s suppressive effects than natural GH.
