When I first started off cycling, I used 22g needles. Glute shots wasnt so bad, delts wasn't so bad. Never ever in my life tried to inject in bi's, tri's or chest.
One day I thought I would give my left calf a try with a 22g. Absolute mistake. Couldn't walk for 2 days. Then I tried a quad injection. Still not recommended. Long story short it didn't take me long to go to a 25g and it makes a huge difference