When i was using Rips i bumped it to 5 ius daily right away, i couldnt move at all, from my elbows, knees, lower back you name it everything hurt so bad, it seem like my joints were going to break, also my feet were so swollen that it wasnt even funny. I drop it to 2 ius and everything went away except my swollen feet, i kept at it for a while like that and then i bumped it to 4 ius with no problems, sometimes i would use more up to 6-7 ius daily but i would do that just for a few days and then i would go back down to 4 ius.