AllTheWay
TID Lady Member
- Mar 17, 2011
- 4,240
- 411
yes, i know, more copy and paste but it is needed for reference sake.
i have just entered the peptide world and am trying to figure it out in a common sense sort of way. hence the brief abstracts and my thoughts on them. i am not saying i have it figured out, i am just placing my thoughts out there and curious as to others peoples thoughts.
it seems that there might be some confusion as to what the peptides or atleast GHRP-2 and GHRP-6 are supposed to do or how they work. it was my understanding that they are used to cause the pituitary to secrete GH. they do not act upon the individual cells of the body like GH but rather they stimulate the body to produce its own GH. so their effect or actions are therefore to release GH and thereby they essentially will have the same type action as injecting GH itself only less so because we are stimulating release of GH and not injecting it directly.
GH-releasing peptides (GHRPs) are synthetic peptides that bind to specific receptors and thereby stimulate the secretion of pituitary GH. In vivo it is uncertain whether these peptides act directly on somatotroph cells or indirectly via release of GHRH from the hypothalamus. In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls. Basal serum GH levels were lower in the GHD group compared with controls [0.11 +/- 0.11 (range, <0.04 to 0.38) vs. 0.59 +/- 0.76 microg/L (range, 0.04-2.12 microg/L); P = 0.052]. After GHRP-2 administration there was a 4.5-fold increase in serum GH relative to baseline values in the GHD group (0.49 +/- 0.41 vs. 0.11 +/- 0.11 microg/L; P = 0.002), which was significantly less than the 79-fold increase in the control group (46.8 +/- 17.6 vs. 0.59 +/- 0.76 microg/L; P = 0.008). Basal and post-GHRP-2 serum levels of ACTH, cortisol, and PRL were similar in both groups. Basal levels of serum TSH were significantly higher in the GHD group than in the control group (3.23 +/- 2.21 vs. 1.37 +/- 0.34 microIU/mL; P = 0.003). TSH levels in both groups did not change after GHRP-2 administration. These results suggest that an intact GHRH signaling system is not an absolute requirement for GHRP-2 action on GH secretion and that GHRP-2 has a GHRH-independent effect on pituitary somatotroph cells.
Growth hormone-releasing peptide-2 s... [J Clin Endocrinol Metab. 2001] - PubMed - NCBI
Growth hormone (GH)-releasing peptides (GHRPs), a family of synthetic oligopeptides which stimulate GH release, were identified more than a decade ago. The effects of these peptides on GH release have been described in vivo and in vitro, in both animals and humans, using various doses and administration routes. It is generally accepted that GHRPs stimulate the release of GH by acting at the level of the pituitary through a receptor different to that for the endogenous GH-releasing hormone (GHRH)i][/
Growth hormone-releasing peptides: clinical and bas... [Horm Res. 1996] - PubMed - NCBI
it would appear that GHRPs do indeed stimulate GH release. when we inject them we are causing a release of GH. the peptides in and of themselves have no affect on the bodies fat metabolism etc but do so by causing release of GH. so we should take them with pretty much the same idea in mind that we would if we were injecting GH just expecting less because we are not overloading the system with GH like if we injected GH.
i have just entered the peptide world and am trying to figure it out in a common sense sort of way. hence the brief abstracts and my thoughts on them. i am not saying i have it figured out, i am just placing my thoughts out there and curious as to others peoples thoughts.
it seems that there might be some confusion as to what the peptides or atleast GHRP-2 and GHRP-6 are supposed to do or how they work. it was my understanding that they are used to cause the pituitary to secrete GH. they do not act upon the individual cells of the body like GH but rather they stimulate the body to produce its own GH. so their effect or actions are therefore to release GH and thereby they essentially will have the same type action as injecting GH itself only less so because we are stimulating release of GH and not injecting it directly.
GH-releasing peptides (GHRPs) are synthetic peptides that bind to specific receptors and thereby stimulate the secretion of pituitary GH. In vivo it is uncertain whether these peptides act directly on somatotroph cells or indirectly via release of GHRH from the hypothalamus. In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls. Basal serum GH levels were lower in the GHD group compared with controls [0.11 +/- 0.11 (range, <0.04 to 0.38) vs. 0.59 +/- 0.76 microg/L (range, 0.04-2.12 microg/L); P = 0.052]. After GHRP-2 administration there was a 4.5-fold increase in serum GH relative to baseline values in the GHD group (0.49 +/- 0.41 vs. 0.11 +/- 0.11 microg/L; P = 0.002), which was significantly less than the 79-fold increase in the control group (46.8 +/- 17.6 vs. 0.59 +/- 0.76 microg/L; P = 0.008). Basal and post-GHRP-2 serum levels of ACTH, cortisol, and PRL were similar in both groups. Basal levels of serum TSH were significantly higher in the GHD group than in the control group (3.23 +/- 2.21 vs. 1.37 +/- 0.34 microIU/mL; P = 0.003). TSH levels in both groups did not change after GHRP-2 administration. These results suggest that an intact GHRH signaling system is not an absolute requirement for GHRP-2 action on GH secretion and that GHRP-2 has a GHRH-independent effect on pituitary somatotroph cells.
Growth hormone-releasing peptide-2 s... [J Clin Endocrinol Metab. 2001] - PubMed - NCBI
Growth hormone (GH)-releasing peptides (GHRPs), a family of synthetic oligopeptides which stimulate GH release, were identified more than a decade ago. The effects of these peptides on GH release have been described in vivo and in vitro, in both animals and humans, using various doses and administration routes. It is generally accepted that GHRPs stimulate the release of GH by acting at the level of the pituitary through a receptor different to that for the endogenous GH-releasing hormone (GHRH)i][/
Growth hormone-releasing peptides: clinical and bas... [Horm Res. 1996] - PubMed - NCBI
it would appear that GHRPs do indeed stimulate GH release. when we inject them we are causing a release of GH. the peptides in and of themselves have no affect on the bodies fat metabolism etc but do so by causing release of GH. so we should take them with pretty much the same idea in mind that we would if we were injecting GH just expecting less because we are not overloading the system with GH like if we injected GH.
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