B-6...does it help lower prolactin levels
MAYO
Bad Mother
- Sep 27, 2010
- 2,159
- 676
Not just plain 'ol B6, there is a coenzyme called P-5-P. That at 300mg a day is what I have read to reduce prolactin. Haven't tried it, I just use a low dose of Prami. IF I found a reliable person to verify that it can be used to reduce prolactin, I would definately try it. P5P is much cheaper than Prami.
AWARE72
MuscleHead
- Oct 17, 2010
- 323
- 18
angelo212
Member
- Sep 22, 2010
- 16
- 0
P-5-P is really talked about alot on the prohormone forums. A simple google search will show you it's popularity for prolactin and there are numerous studies. Here's a few. BJ Clin Endocrinol Metab 1976 Mar;42(3):603-6
Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway.
Delitala G, Masala A, Alagna S, Devilla L.
A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.
===============================
N Engl J Med 1982 Aug 12;307(7):444-5
Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise.
Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori A.
=====================================
Boll Soc Ital Biol Sper 1984 Feb 28;60(2):273-8
[Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]
[Article in Italian]
Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C.
The influence of vitamin B6 in a dosage of 300 mg X 2 in 24 hrs, on circadian rhythm of plasmatic ACTH, cortisol, prolactin and somatotropin have been studied in 10 normal women. After vitamin B6 24 hrs pattern of ACTH and cortisol is unchanged; prolactin levels are slightly lower, in a statistically unsignificant proportion the night peak of growth hormone is higher in a statistically significant proportion (p. 0.05). The effect of vitamin B6 is likely to me mediated by dopaminergic receptors at hypothalamic level as previous studies by other Authors appear to prove.
Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway.
Delitala G, Masala A, Alagna S, Devilla L.
A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.
===============================
N Engl J Med 1982 Aug 12;307(7):444-5
Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise.
Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori A.
=====================================
Boll Soc Ital Biol Sper 1984 Feb 28;60(2):273-8
[Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]
[Article in Italian]
Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C.
The influence of vitamin B6 in a dosage of 300 mg X 2 in 24 hrs, on circadian rhythm of plasmatic ACTH, cortisol, prolactin and somatotropin have been studied in 10 normal women. After vitamin B6 24 hrs pattern of ACTH and cortisol is unchanged; prolactin levels are slightly lower, in a statistically unsignificant proportion the night peak of growth hormone is higher in a statistically significant proportion (p. 0.05). The effect of vitamin B6 is likely to me mediated by dopaminergic receptors at hypothalamic level as previous studies by other Authors appear to prove.
Who is viewing this thread?
There are currently 0 members watching this topic