Problem is some aas like nandrolone being a synthetic progestin but also containing androgenic properties as well stimulate other factors that can reduce cardiac function.
You run deca at high enuff doses and you will notice you breath harder and your endurance starts to suck. Personal experience at 400 I noticed nothing realy as far as endurance, 600-900 mg I got short winded and didn't have the cardio endurance to do high rep squats like I did a couple weeks before.
ND treatment increased: LV-ACE activity, AT1 receptor expression, aldosterone synthase (CYP11B2) and 11-ß hydroxysteroid dehydrogenase 2 (11ßHSD2) gene expression and inflammatory markers, TGFß and osteopontin.
long term use of nandrolone at higher doses shows an increase of myocardial collagen volume fraction (CVF) ,collagen I- III. increased CVF can lead to Hypertrophic Cardiomyopathy .
Hypertrophic Cardiomyopathy (HCM), interstitial myocardial fibrosis is an important histological modification that has been associated with sudden death and evolution toward myocardial dilation. Myocardial expression is by a effect of OPN which induces Col I-mediated cardiac fibrosis and that is what leads to progressive ventricular dilatation and cardiac dysfunction .chronic aldosterone or angiotensin II also show some of the same effects on the right and left ventricles as well. ACE activity being upregulated by aas correlates with the degree of hypertrophy in volume- and pressure-overload of congestive heart failure (CHF) and with diastolic wall stress in mitral regurgitation .
Not to scare everyone or maybe I should, extremely high doses of most aas for sure will put some serious stress on the heart. Ace inhibitors would be a good idea if your going to run high doses. High ACE activity equals dilated cardiomyopathy.
Regualr heart check-ups are life savers for anyone realy.
