There are certain things that I consider "essential" in maintaining good health and strength, all in moderation of course. These include things that maintain organ and tissue health like vitamins, minerals, fish oils, etc. Just find a source that is as "natural" as possible and make sure it's a good quality raw product. Buying these things in bulk and capping them yourself or putting scoops into your drink can save you some good money. The stuff that we waste money on are the supplements that are "re-branded" as life changing. This includes pretty much any "supplement" by a certain company that rhymes with "Hustle Neck"...
The only supplements I buy are ones that are individual minerals or vitamins with a few exceptions. Stuff that includes several different vitamins/minerals together is ok, but for fish oils, red yeast rice, DHA, vitamin D, etc, I take all that stuff separately. Like I said, I buy the stuff in bulk from a place like purebulk.com and mix it together in a shake or other drink.