I would definitely advise against running tren all year long. If you begin to do this, at least get lab work done frequently. Doing a 2-4 month run of tren, with traditional doses, is going to be hard enough, let alone a year. Tren will hammer your lipids, as does most compounds. Going all year long with screwed up lipids is not the healthiest thing to do. Now dosage will play a factor in all this as well, you may be able to run lower doses for longer periods, but if I were to bet, everybody is probably going to react differently, similar to how they do with trt, and only bloodwork is going to catch this. Having other compounds in at the same time is also going to exacerbate the negatives. Now something I still don't recommend, but will mention, is that Doggcrapp mentioned he ran a long-term dosage of Tren for most of a year, but he was using only 7mg's on M/W/F of the week. He mentioned no sides in bloods, except he decided to quite things when he seen that his PSA levels started to rise.