I run mine ed. The vials I currently have contain 15iu so I'll do the first day of a new vial at 3iu and then its 2iu till the next vial. I also noticed doing it IM has worked a lot better. I can't imagine running 10iu of rips ed, man my hands hurt just thinking about that. Zomb131 did you have to work up to that or did you just jump in head first?