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Contraceptive: Test E + Progesterone

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MuscleHead
Sep 9, 2010
3,441
643
#1
Another interesting article:

J Androl. 2005 May-Jun;26(3):405-13.

Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial.
Anawalt BD, Amory JK, Herbst KL, Coviello AD, Page ST, Bremner WJ, Matsumoto AM.

Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108, USA. [email protected]

Abstract
The development of a safe, well-tolerated, effective, and reversible male hormonal contraceptive would be a major clinical advance for couples planning their family size and for control of population growth. High-dosage parenteral testosterone (T) esters alone or in combination with a progestogen (eg, depot medroxyprogesterone) have been shown to confer effective and reversible male contraception in clinical trials, but these regimens are associated with weight gain and suppression of serum high-density lipoprotein cholesterol (HDL) levels. We have previously demonstrated that intramuscular T enanthate 100 mg weekly plus oral levonorgestrel (LNG) 125, 250, or 500 microg daily suppresses spermatogenesis to levels associated with effective contraception, but there is a LNG-dosage-dependent effect of weight gain and HDL suppression. We hypothesized that intramuscular T enanthate 100 mg weekly plus a very low dosage of oral LNG would effectively suppress spermatogenesis in normal men without inducing weight gain or HDL suppression. We conducted a randomized trial comparing 6 months of intramuscular T enanthate (100 mg weekly) plus 31.25 microg of oral LNG daily (T+LNG 31; n = 20) or 62.5 microg of oral LNG daily (T+LNG 62; n = 21). The 2 regimens were equally effective in suppressing spermatogenesis to azoospermia, fewer than 1 million sperm/mL and fewer than 3 million sperm/mL (T+LNG 31 [60%, 85%, and 90%] vs T+LNG 62 [62%, 91%, and 95%] for azoospermia, fewer than 1 million and fewer than 3 million, respectively; P = NS). The T+LNG 31 group did not gain weight (0.25 +/- 1.08 kg; P = NS compared with baseline),but the T+LNG 62 group gained 2.5 +/- 0.77 kg (P < .05 compared with baseline). Serum HDL cholesterol levels declined significantly in both groups (percentage decline month 6 of treatment vs baseline: 12.0% +/- 2.6% and 15.1% +/- 3.0%; P < .05 for T+LNG 31 and 62 respectively). Serum low-density lipoprotein cholesterol levels also declined in both groups (percentage decline month 6 of treatment vs baseline: 6.9 +/- 3.9 and 6.0% +/- 4.1%; P < .05 for T+LNG 31 and P = NS for T+LNG 62). There were no clinically significant adverse events or significant changes in hematology or chemistry profiles in either group during the study. We conclude that 1) intramuscular T plus oral LNG has a very potent synergistic effect in suppressing spermatogenesis at LNG dosages equal to or lower than dosages used in common female oral contraceptive regimens and 2) large, long-term contraceptive efficacy trials should be conducted with a variety of androgen-progestogen combinations including long-acting T formulations such as depot T pellets or intramuscular T undecanoate plus depot LNG or very low dosage oral LNG.
 
FlyingDragon

FlyingDragon

VIP Member
Nov 4, 2010
3,368
1,574
#2
The guy who ate at Mcdonalds for 30 days in a row did a special on HRT (Morgan Spurlock). The test subject had 100% dead swimmers after 1 or 2 shots. Dscontinued injection after the 2nd week if I remember correctly. Toward the end of the 30 days, the swimmers came back.
 
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MuscleHead
Sep 9, 2010
3,441
643
#3
The guy who ate at Mcdonalds for 30 days in a row did a special on HRT (Morgan Spurlock). The test subject had 100% dead swimmers after 1 or 2 shots. Dscontinued injection after the 2nd week if I remember correctly. Toward the end of the 30 days, the swimmers came back.
Very interesting. From what I've read I would have to assume that some men can still produce sperm while on test, but 60%+ likely have no production at all. It looks like they add the progesterone just to be sure. I wonder what the effects of long term progesterone would be, even though it's a low dose? Possible gyno?
 
JackD

JackD

Senior Moderators
Staff Member
Sep 16, 2010
5,066
538
#4
Very interesting. From what I've read I would have to assume that some men can still produce sperm while on test, but 60%+ likely have no production at all. It looks like they add the progesterone just to be sure. I wonder what the effects of long term progesterone would be, even though it's a low dose? Possible gyno?
I don't think gyno would be possible with that low of a dose. Long term effects, for those unhealthy morons, I would think more cardiovascular disease, maybe also after a long term use the sperm count that does come back might be really low. It's hard to tell, 6 months isn't a long time.
 
D

DIEZEL

MuscleHead
Jan 26, 2011
283
10
#5
The guy who ate at Mcdonalds for 30 days in a row did a special on HRT (Morgan Spurlock). The test subject had 100% dead swimmers after 1 or 2 shots. Dscontinued injection after the 2nd week if I remember correctly. Toward the end of the 30 days, the swimmers came back.
I seen that one, all dead sperm and the wife gave the hubby hell so he quit. But i had 2 kids on cycle so it doesint work very well.
 
N

Neveroutgunned

Member
Feb 9, 2011
12
0
#6
bump D. I definitely knocked a chick up 12 wks into a 16 wk gig.
 
FlyingDragon

FlyingDragon

VIP Member
Nov 4, 2010
3,368
1,574
#8
For most the science states the swimmers should be dead, for the few lucky one's, your swimmers must be on something....lol
 
marx

marx

MuscleHead
Sep 29, 2010
4,671
625
#9
Hope mine are all dead...
YES! My perspective.

The science says some folks sperm just up and stop living, bingo- and that other folks just get sperm impaired. Each condition gets a separate Latin word...
 
marx

marx

MuscleHead
Sep 29, 2010
4,671
625
#10
DIEZEL, respectfully gotta say: your wife is drop dead beautiful, so your swimmers got vital enthusiasm.
 
D

DIEZEL

MuscleHead
Jan 26, 2011
283
10
#11
DIEZEL, respectfully gotta say: your wife is drop dead beautiful, so your swimmers got vital enthusiasm.
Thanks!! I was expecting non stop pussy at least for a month or 2. She had the IUD removed and 13 days later she knocked up, and i was running a gram of test along with other things...go figure right.
 
fixxer

fixxer

MuscleHead
Dec 15, 2010
993
162
#12
DIEZEL, respectfully gotta say: your wife is drop dead beautiful, so your swimmers got vital enthusiasm.
x2 and if you knew diez you'd be surprised because he looks like a crackbaby with a touch of down syndrome.
 
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