Unless it's really infected and needs to be drained then I rub some topical hydrocortisone cream on it a few times a day for a couple of days and that usually hooks it up.
If it's not hot, red and you're not feeling flu-like symptoms then I'd use heat and a combo of benadryl, ibuprofen or naproxen and leave it alone other than that. It'll take some time for it to dissipate but it will go away.
I have a small one in each ass cheek every week from t400. It subsides after 3 days or so. I won't dare put that shit in my quad because I know what will happen. I'll try it in my delt soon but I'm sure I'm going to have a knot there for a few days too...
Update on this. It is FINALLY starting to subside. Much better than last week. Knot is still there, but not near as big. Lesson learned here. As long as I have been in this, I should have known better lol. Thanks for all the replies guys