Bigtex
VIP Member
- Aug 14, 2012
- 2,063
- 3,348
My wife has tried all of the GLP-1s and and got very little results. Of course in all of the research they found 18.6% of the subjects were non-responders. My wife fell in that category with all of them. On a chance I got my wife a product called Tesofensine and my wife tired it earlier this year and seemed to have good results. She gave it up and tried all the GLP-s with very little result. I was told this particular product had been improved and is a much better product so I got my wife 4 bottles. She started on it yesterday and tells me she is absolutely NOT hungry and has eaten a small amount of polenta in 24 hours.
Tesofensine is a triple monoamine reuptake inhibitor that blocks the reabsorption of serotonin, norepinephrine, and dopamine in the brain. This increases the levels of these neurotransmitters, which regulate appetite, mood, and energy expenditure
In a 48-week extension study (TIPO-4), patients previously treated with tesofensine 0.5 mg achieved a total mean weight loss of 13–14 kg,
Conclusion
Tesofensine is a promising weight loss medication, demonstrating significant efficacy (up to 10.6% body weight loss in 6 months at 1.0 mg, with 0.5 mg being nearly as effective) by suppressing appetite and potentially increasing energy expenditure. It outperforms many existing weight loss drugs but is not yet FDA-approved, pending further long-term studies. Common side effects like dry mouth, nausea, and insomnia are generally mild, but dose-dependent increases in heart rate and blood pressure at higher doses require careful monitoring. The 0.5 mg dose appears to offer the best balance of efficacy and safety.
Guys, this has only been through Clinical II trials, no long term data is available yet. But it seem to be effective on this that IMHO have food addictions. My wife is Italian and was raised with using food as a reward and act of love. I was raised the opposite and seem to not have food issues.
My wife absolutely loves this stuff and I will keep you guys up on how it goes.
Interesting
Food addiction arises from a complex interplay of genetic factors (e.g., dopamine signaling, appetite regulation genes) and cultural influences (e.g., food environment, social norms, learned behaviors). Genetics can predispose individuals to compulsive eating, but cultural factors, particularly the availability of ultra-processed foods and societal eating habits, significantly amplify this risk. In cultures with healthier food environments or restrictive norms, genetic predispositions may be less expressed. Addressing food addiction requires considering both biological vulnerabilities (e.g., through medical interventions like tesofensine) and cultural interventions (e.g., improving food environments, education on healthy eating).
Tesofensine is a triple monoamine reuptake inhibitor that blocks the reabsorption of serotonin, norepinephrine, and dopamine in the brain. This increases the levels of these neurotransmitters, which regulate appetite, mood, and energy expenditure
In a 48-week extension study (TIPO-4), patients previously treated with tesofensine 0.5 mg achieved a total mean weight loss of 13–14 kg,
Conclusion
Tesofensine is a promising weight loss medication, demonstrating significant efficacy (up to 10.6% body weight loss in 6 months at 1.0 mg, with 0.5 mg being nearly as effective) by suppressing appetite and potentially increasing energy expenditure. It outperforms many existing weight loss drugs but is not yet FDA-approved, pending further long-term studies. Common side effects like dry mouth, nausea, and insomnia are generally mild, but dose-dependent increases in heart rate and blood pressure at higher doses require careful monitoring. The 0.5 mg dose appears to offer the best balance of efficacy and safety.
Guys, this has only been through Clinical II trials, no long term data is available yet. But it seem to be effective on this that IMHO have food addictions. My wife is Italian and was raised with using food as a reward and act of love. I was raised the opposite and seem to not have food issues.
My wife absolutely loves this stuff and I will keep you guys up on how it goes.
Interesting
Food addiction arises from a complex interplay of genetic factors (e.g., dopamine signaling, appetite regulation genes) and cultural influences (e.g., food environment, social norms, learned behaviors). Genetics can predispose individuals to compulsive eating, but cultural factors, particularly the availability of ultra-processed foods and societal eating habits, significantly amplify this risk. In cultures with healthier food environments or restrictive norms, genetic predispositions may be less expressed. Addressing food addiction requires considering both biological vulnerabilities (e.g., through medical interventions like tesofensine) and cultural interventions (e.g., improving food environments, education on healthy eating).
