ECA stack?
While both EPHEDRINE and CAFFEINE increase the metabolic rate and have anoretic effects, WHY is ASPIRIN being used?
jim
ECA stack?
While both EPHEDRINE and CAFFEINE increase the metabolic rate and have anoretic effects, WHY is ASPIRIN being used?
jim
I've been wondering this a lot lately dr Jim. I understand the synergistic effect staking ephedrine and caffeine but unsure of the role aspirin plays. I hope to hear something back on this one
I presume it's role would be as a blood-thinner, but I could be wrong.
Thanks for that CBS ~ looks like I was wrong lol.I believe the idea came from a couple of studies on ECA's effect on post-prandial thermogenesis, however, the addition of aspirin only had a small beneficial effect on weight loss in obese subjects. If I remember correctly, the purported mechanism was that aspirin inhibits prostaglandins which prevent the release of adrenaline and noradrenaline, and when combined with caffeine, it supposedly has a synergistic effect that enhances thermogenesis and metabolism by sustaining elevated cAMP levels.
The studies that showed a benefit for aspirin needed around 300 mg tid. Obviously a lot. EC works fine on its own, especially if already lean.
CBS
Thanks CBS BUT the authors didn't compare the EC and the ECA groups to determine if ASA made any difference in thermogenesis and considering the negative impact ANY NSAID may have on protein synthesis (theoretically) I'M NOT BUYING IT.
The only mechanism I'm aware of regarding ASA and "weight loss" involves the uncoupling of oxidative phosphorlation (much like DNP) which increases thermogenesis in VERY HIGH DOSES!
Agreed MATE drop the ASA
Best
JIM
Hey Dr. Jim, for a bronkaid caffeine stack, what dosage of the bronkaid would you recommend. I just started today and only using one tab bronkaid (25mg ephedrine) and one 200mg caffeine tab. I will possibly run that dose split evenly throughout the day for 3 times but also just considering the one time pre workout.
The doses used in most studies were 20mg ephedrine and 200mg caffeine tid. I have no idea about pre-workout - perhaps Jim can advise on that one.
Int J Obes Relat Metab Disord. 1993 Feb;17 Suppl 1:S69-72.Safety and efficacy of long-term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture.
Toubro S[SUP]1[/SUP], Astrup AV, Breum L, Quaade F.
Abstract
In a randomized, placebo-controlled, double blind study, 180 obese patients were treated by diet (4.2 MJ/day) and either an ephedrine/caffeine combination (20mg/200mg), ephedrine (20mg), caffeine (200mg) or placebo 3 times a day for 24 weeks. 141 patients completed this part of the study. All medication was stopped between week 24-26 in order to catch any withdrawal symptoms. From week 26 to 50, 99 patients completed treatment with the ephedrine/caffeine compound in an open trial design, resulting in a statistically significant (p = 0.02) weight loss of 1.1kg. In another randomized, double-blind, placebo-controlled 8 week study on obese subjects we found the mentioned compound showed lean body mass conserving properties. We conclude that the ephedrine/caffeine combination is effective in improving and maintaining weight loss, further it has lean body mass saving properties. The side effects are minor and transient and no withdrawal symptoms have been found.
Int J Obes Relat Metab Disord. 1993 Dec;17 Suppl 3:S73-7; discussion S82.The acute and chronic effects of ephedrine/caffeine mixtures on energy expenditure and glucose metabolism in humans.
Toubro S[SUP]1[/SUP], Astrup A, Breum L, Quaade F.
Abstract
This paper describes a 24-week open follow-up trial with reduced obese patients all receiving an ephedrine/caffeine combination (20 mg/200 mg) three times a day. The study was a continuation of a previous 24-week double-blind placebo-controlled study where the ephedrine/caffeine mixture had shown superior weight-reducing properties when compared with either ephedrine alone (20 mg) or caffeine alone (200 mg) three times a day. The medication was stopped between weeks 24-26 in order to evaluate withdrawal symptoms. The follow-up period was from weeks 26 to 50. Of 127 patients included, 99 completed the follow-up treatment, which resulted in an additional weight loss of 1.1 kg (P = 0.02). Adverse drug reactions were all minor and temporary. We conclude that the ephedrine/caffeine combination is safe and effective in long-term treatment in improving and maintaining weight loss. The side-effects are minor and transient and no clinically relevant withdrawal symptoms have been observed.
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