Hybrid Strength Training...

[BrotherIron]

Quick in and out again.

WK5 - WED
Floor Press - 95, 125, 125 x7
Standing OH Pin Press - 85, 105, 105 x7
Accessories: CloseMag Grip Low Row, Straightbar Pressdown

I'm excited to begin the next block. Like I said I'm going to keep triples in and not put in any heavy singles, not yet. Ankle isn't 100% as I've seen but it handles heavy triples well.

 

[BrotherIron]

I think what people miss is what happens between injections of NAD+. Even though the molecule itself clears quickly from the bloodstream, the cellular effects don’t shut off when plasma levels drop.

Here’s what’s still happening during the in-between days:

1. The intracellular NAD⁺ pool stays elevated.
Once NAD⁺ gets inside the cell, it enters the mitochondrial and nuclear pools, and those don’t instantly disappear. Cells slowly use that NAD⁺ over time for energy production and repair processes. You don’t need constant dosing to maintain that pool.

2. Sirtuin activation continues.
SIRT1, SIRT3, and other sirtuins stay active as long as intracellular NAD⁺ is adequate. These regulate mitochondrial biogenesis, stress resistance, metabolic efficiency, and longevity pathways. All of which remain elevated for days after an injection.

3. Mitochondrial function remains elevated.
Improved oxidative phosphorylation doesn’t vanish when serum NAD⁺ drops. The mitochondria stay in a more “efficient” state because the NAD⁺/NADH ratio has shifted. This supports cleaner energy, better recovery, and better training performance between doses.

4. DNA repair and oxidative stress control don’t stop.
PARPs and other repair enzymes rely on intracellular NAD⁺, not serum levels. Once the NAD⁺ pool is replenished, your cells continue chipping away at oxidative damage and DNA repair for days.

5. Metabolic signaling stays in the ‘on’ position.
NAD⁺ isn’t a stimulant. It’s a cofactor. Once you restore it, your metabolic processes run more efficiently on their own. You don’t need constant dosing to keep those systems moving.

In other words:
NAD⁺ injections create a sustained intracellular environment that stays active between doses, even though the molecule isn’t still floating in the bloodstream.

That’s why I believe 3x a week will work. I'm supporting the internal system long after the injection window, not trying to maintain artificially high serum level all day.

 

[BrotherIron]

Another thing worth pointing out is how NAD⁺ and GHK-Cu work in tandem, because that’s exactly why I chose this stack. They’re not overlapping compounds, they hit two completely different sides of recovery, performance, and longevity, and they complement each other almost perfectly.

GHK-Cu works at the tissue level.
It lowers inflammation, improves collagen structure, calms down irritated connective tissue, softens chronic tightness, and helps the body repair tendons, ligaments, skin, and fascia. It’s essentially “structural maintenance,” and for someone who trains the way I do: heavy squats, pulls, carries, pin presses, speed work. Keeping tissue quality high is everything. It prevents flare-ups, improves durability, and lets me stay consistent.

NAD⁺, on the other hand, works at the cellular and mitochondrial level.
It supports clean energy production, improves the NAD⁺/NADH ratio, activates sirtuins, boosts recovery between sessions, stabilizes mood, improves oxidative stress control, and keeps the metabolism running efficiently. This is what will hopefully give me cleaner energy, better CNS resilience, and smoother recovery on heavy weeks.

Put them together and you get a 2-layer system:

• GHK-Cu fixes the body itself
• NAD⁺ upgrades the machinery running inside the body

One handles the structural, the other handles the cellular.
One helps tissue recover, the other helps the system recover.
One keeps the joints and soft tissue healthy, the other keeps the mitochondria and nervous system strong.

That’s why I chose this duo.
I’m not chasing quick fat loss or dramatic cosmetic changes. I’m building long-term resilience, better performance, cleaner energy, and a healthier baseline heading into the future. NAD⁺ + GHK-Cu is the most sustainable, cost-effective, and intelligent combo for the goals I have right now, especially at my age and training the way I train.

 

[Cohiba]

Let us know how it works out!

 

[BrotherIron]

Let us know how it works out!

Absolutely, I’m logging everything in here. It’s been way too long since I’ve run a real experiment, so this is the perfect setup to test my hypothesis and see what actually holds up in practice.

I’ll start with GHK-Cu for the first two months, then introduce NAD⁺ afterward so I can clearly see what each one does on its own.

I’ll track the whole thing week-by-week so I’ll be able to see what’s placebo and what’s a true biological shift. Should be interesting.

 

[Cohiba]

Absolutely, I’m logging everything in here. It’s been way too long since I’ve run a real experiment, so this is the perfect setup to test my hypothesis and see what actually holds up in practice.

I’ll start with GHK-Cu for the first two months, then introduce NAD⁺ afterward so I can clearly see what each one does on its own.

I’ll track the whole thing week-by-week so I’ll be able to see what’s placebo and what’s a true biological shift. Should be interesting.

I take 500mg NMN daily, I like it.

 

[BrotherIron]

I take 500mg NMN daily, I like it.

That’s awesome you respond well to NMN, it seems like a lot of people do. It’s definitely one of the better precursors. The only reason I’m going with injectable NAD⁺ instead of precursors is because NMN still has to survive digestion, get transported, and then go through the NAMPT conversion pathway to actually become NAD⁺. That whole conversion bottleneck slows with age and varies a lot from tissue to tissue.

Injectable NAD⁺ kind of skips all of that. You’re delivering the active molecule directly into circulation, so you actually raise intracellular NAD⁺ levels without relying on the conversion steps. It’s not that NMN is bad at all, it just works differently. I’m basically testing the “direct route” for a while.

 

[BrotherIron]

WK5 - THUR
Conditioning: KB Swings / Sled Pulls (Forward & Backwards) / Box Jumps
18 min total time - 7 sets
30lbs KB Swing - 6 per set
50lbs on Sled - Down & Back
16" Box Jumps - 4 per set