SHINE
Friends Remembered
- Oct 11, 2010
- 5,047
- 601
HCG and Spermatogenesis
Interesting article here about HCG ability of stimulating spermatogenesis. These guys apparently found that in patients that went hypogonadal after puberty, HCG was 100% effective in stimulating spermatogenesis, although we are talking about a small sample size (6). In the ones that went hypogonadal during puberty, HMG was required. The ones that had a testicle missing from the scrotum on top of that were in trouble though...
Maybe good news to anyone on HRT trying to knock the old lady up lol.
Stimulation of Spermatogenesis by Gonadotropins in Men with Hypogonadotropic Hypogonadism
David M. Finkel, M.D., Jennifer L. Phillips, B.A., and Peter J. Snyder, M.D.
N Engl J Med 1985; 313:651-655September 12, 1985
Abstract
We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism. When 21 men with hypogonadotropic hypogonadism were treated with human chorionic gonadotropin, the sperm count increased to within the normal range in the 6 in whom hypogonadism had begun after puberty, but in only 1 of the 15 in whom it had begun before puberty (P<0.002). When the remaining 14 men with prepubertal hypogonadism were treated with human menopausal gonadotropin in addition to human chorionic gonadotropin, the sperm count increased to normal in 5 of the 7 who had not had cryptorchidism, but in only 1 of the 7 who had (P<0.05). The need for human menopausal gonadotropin as a replacement for follicle-stimulating hormone could not be predicted by pretreatment serum and urinary levels of follicle-stimulating hormone.
We conclude that gonadotropin treatment will usually increase the sperm count to normal in men with hypogonadotropic hypogonadism, unless cryptorchidism has occurred. The need for human menopausal gonadotropin treatment appears to depend on the time of onset of hypogonadism. (N Engl J Med 1985; 313:651–5.)
Interesting article here about HCG ability of stimulating spermatogenesis. These guys apparently found that in patients that went hypogonadal after puberty, HCG was 100% effective in stimulating spermatogenesis, although we are talking about a small sample size (6). In the ones that went hypogonadal during puberty, HMG was required. The ones that had a testicle missing from the scrotum on top of that were in trouble though...
Maybe good news to anyone on HRT trying to knock the old lady up lol.
Stimulation of Spermatogenesis by Gonadotropins in Men with Hypogonadotropic Hypogonadism
David M. Finkel, M.D., Jennifer L. Phillips, B.A., and Peter J. Snyder, M.D.
N Engl J Med 1985; 313:651-655September 12, 1985
Abstract
We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism. When 21 men with hypogonadotropic hypogonadism were treated with human chorionic gonadotropin, the sperm count increased to within the normal range in the 6 in whom hypogonadism had begun after puberty, but in only 1 of the 15 in whom it had begun before puberty (P<0.002). When the remaining 14 men with prepubertal hypogonadism were treated with human menopausal gonadotropin in addition to human chorionic gonadotropin, the sperm count increased to normal in 5 of the 7 who had not had cryptorchidism, but in only 1 of the 7 who had (P<0.05). The need for human menopausal gonadotropin as a replacement for follicle-stimulating hormone could not be predicted by pretreatment serum and urinary levels of follicle-stimulating hormone.
We conclude that gonadotropin treatment will usually increase the sperm count to normal in men with hypogonadotropic hypogonadism, unless cryptorchidism has occurred. The need for human menopausal gonadotropin treatment appears to depend on the time of onset of hypogonadism. (N Engl J Med 1985; 313:651–5.)
Last edited: