Enclomiphene experiences?

[norm]

A buddy asked about this--enclomiphene citrate. Had never heard of it before. Did a search here and it is mentioned in another TRT thread.
Anyone else tried it or know anyone who's used it? Basically, did it work very well?
Here's a link to an interesting study--

Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

www.ncbi.nlm.nih.gov

 

[Glycomann]

I have some but have not tried it yet.

 

[genetic freak]

Vigorous Steve has covered it quite a bit: https://www.youtube.com/@VigorousSteve/search?query=enclomiphene

Kurt Havens talks about it here:

 

[CFM]

Unrelated.......I love me a clomid & HCG cycle. I am interested in knowing more about enclomiphene citrate.

Preliminary investigation the dosage required is not cost effective for me.

 

[CFM]

I have some but have not tried it yet.

Dose and duration you are planning?

 

[Massive G]

Unrelated.......I love me a clomid & HCG cycle. I am interested in knowing more about enclomiphene citrate.

Preliminary investigation the dosage required is not cost effective for me.

I used to love HCG back in the day....but not sure what changed but since 2005 every type and even microdosing HCG I get nauseous and achy breaky . Includes scripted USPharm and Pregnyl as well.
Some research companies sell enclomiphene...amino asylum comes to mind but a quick search may yield more results.
I never had a problem with clomid so the extra expense wouldn't be worth it for me. I have thought of trying HMG but the cost is also prohibitive for me.

 

[CFM]

@Massive G
I like to take a break once a year from TRT and run HCG and Clomid. Cannot say I get aches and pains and I do run HCG with Test year round. I figure I am 60 with 49 years of lifting hence my hair hurts.

 

[Glycomann]

Dose and duration you are planning?

I'm not sure yet. The way to run it would be to come off after 2-4 week on hCG last two weeks of cycle and 2 weeks after. Introduce enclom after a week off and run for 4 weeks. Test 8 weeks after that. So looking at a full 12 weeks off to see if the restart took. I probably wont do that the first ime I use it. I will probably do the hCG end of cycle, 2 weeks after and 1 week after last shot add in enclom. Then at week 6 off test to see where test, LH and FSH are just to see if the drug works as advertised.

 

[Wilson6]

Unrelated.......I love me a clomid & HCG cycle. I am interested in knowing more about enclomiphene citrate.

Preliminary investigation the dosage required is not cost effective for me.

Clomiphene is a mix of two isomers zuclomiphene (38%) and enclomiphene (62%). Zuclomiphene is more estrogenic, whereas enclomiphene is more anti-estrogenic, thus pure ENCL is more efficacious for hypogonadal males and raising testosterone. The only issue with these drugs is that they reduce IGF-I and blunt the GH response. The argument is that IGF-I causes cancer (although the GH/cancer association is weak and discussed in another thread) so if one raises T and decreases IGF-I, one would reduce the prostate cancer risk, also assuming T causes prostate cancer and we now know it does not. GH is a key regulator of hepatic and extra-hepatic (muscle) IGF-I production, and GH regulates myostatin production (low GH = higher myostatin = blunted muscle hypertrophy). I would like to see is a study where subjects are given T + hCG (to maintain fertility) or enclomiphene to raise T to about the same levels, then measure changes in lean/fat mass, BMD, QOL, hormones, erectile function, libido, etc of a year period time. That would really help sort this out. A combined ENCL + GH study would also be interesting.

 

[DocOxRedox]

A buddy asked about this--enclomiphene citrate. Had never heard of it before. Did a search here and it is mentioned in another TRT thread.
Anyone else tried it or know anyone who's used it? Basically, did it work very well?
Here's a link to an interesting study--

Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

www.ncbi.nlm.nih.gov

My insurance wouldn't cover enclomiphene w/o addtional headache AND no one in my region compounds it. I am currently on clomid 25mg/day and 25mg of exemestane EOD my total T is 807 and free is 417. I will be likely switching to either anastozole or letrozole for a better terminal half-life, therefore more stable long term blood plasma levels. For a quick cost comparison I think I'm paying about $30/month for my combo vs the $130 or so depending on the online vendor.

Several studies show that AI's reduce SHBG so I suspect that is why free/bio test is going up. I also came across one yesterday in a Letrozole study that had the following results:

Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E(2) levels were stable throughout the week and during the 6-month treatment period.

It appears that the potential for some to have a positive response that could mimic teenage/early 20's free/bio available potential is there. Admittedly, my research revolves around studies and their results on LH, FSH, SHBG and bio/free test. Total T doesn't mean squat if your SHBG is chewing up its bioavailibility.

I'd love to see someone here on injectable HRT/TRT add an AI for 2 months just to see what happens to free/bio T, before and after. In theory it should rise but I cannot find any studies yet that have been conducted as such and/or only abbrevated abstracts are available on pubmed/NCBI.