Why Microdosing Retatrutide Is A Total Failure

[Wilson6]

Agree with this, can’t knock what works…
There’s a few peptide calculators out there to find levels over time with half life / clearance rate.

I keep it simple and just do what Wilson6 says because he’s the smartest guy on the boards

There's guys way smarter than me on the board. We all look at the same problems or questions differently and that yields far more useful info. Mine is just another perspective on what will likely never be studied clinically, but has significant clinical relevance.

 

[DieYoungStrong]

There's guys way smarter than me on the board. We all look at the same problems or questions differently and that yields far more useful info. Mine is just another perspective on what will likely never be studied clinically, but has significant clinical relevance.

There's a lot of smart guys around here. But your knowledge of things for the aging meathead is off the charts.

 

[tommyguns2]

Big Paul Barnett has put out some content on micro-dosing of Reta that sounds similar to what Dr. Trevor is saying, without all the arrogance and bluster. I haven't checked it out yet, but I will.

I think what both are saying is that Reta is a triple agonist, and with the micro-dosing the first prong is effective, so you'll still see some benefit, but the other two prongs get truncated, and thus there is opportunity loss. Paying for expensive semaglutide, and not seeing all the magic. I'll try to find the episode and copy the link here.

 

[genetic freak]

On top of taking daily magnesium, and fiber added to my smoothie in the morning... I have these magnesium gummies. I can feel when I'm starting to back up. So, when I do I take a literal hand full of the gummies (on top of the daily pill). Clears me right up overnight. Have not had this problem in 8 or 9 months but when I first started on compounded Tirzep I had some rough days. Got sick more than a few times. I call it the fuck around and find out drug.

Magnesium citrate gummies are where it is at. The liquid is 1.7 g of magnesium citrate and will flush the pipes, but is a violent, all-day affair. I found about 1.2 g of the gummies is about perfect when someone gets backed up. If they are still having issues, it is because they are dehydrated.

 

[Ron OG Mouse]

Magnesium citrate gummies are where it is at. The liquid is 1.7 g of magnesium citrate and will flush the pipes, but is a violent, all-day affair. I found about 1.2 g of the gummies is about perfect when someone gets backed up. If they are still having issues, it is because they are dehydrated.

That was my problem when I first started. I was not intaking enough water. I have not needed the lil extra gummies since I increased and monitored my water intake.

 

[tommyguns2]

They talk about this issue in the unwracked podcast, and both Kyle and Andrew are still advocates for the microdosing of GLPs.

here's a graph from GLP plotter showing Reta dosed at 0.25mg ED vs. 1.5mg 1x/week

 

[tommyguns2]

Could the 1x/week dosing recommendation be as simple as the general public is lazy and less apt to comply with ED injections? I'm injecting other peptides and GH daily, so it's no big deal for me.

 

[Wilson6]

They talk about this issue in the unwracked podcast, and both Kyle and Andrew are still advocates for the microdosing of GLPs.

here's a graph from GLP plotter showing Reta dosed at 0.25mg ED vs. 1.5mg 1x/week

View attachment 18084

View attachment 18085

This is why I like 2x/wk. Middle of the road approach. The bottom chart shows the peaks/troughs of 1x/wk dosing. You can argue that the peaks are what drives the optimal results just like dosing T. However, it also drives the sides, like HCT and T. My clients that do a 2x/wk approach avoid the sides (nausea right after the dose, and intense hunger before the next one) and still obtain the same weight loss results. As we've all said a million times, there is no right way for everyone, what works best is what works best for you and that takes some time, journaling, and consistency to figure out (change only one variable at at time and give it some time esp with compounds that have longer t 1/2s). Lastly, you can't take one perspective on something, even if it fits your confirmational bias and run with it. You have to keep an open mind and look at things from 36,000 feet, not ground level. The overall perspective is far more complex, but also more informative relative to making the best decision.

 

[tommyguns2]

This is why I like 2x/wk. Middle of the road approach. The bottom chart shows the peaks/troughs of 1x/wk dosing. You can argue that the peaks are what drives the optimal results just like dosing T. However, it also drives the sides, like HCT and T. My clients that do a 2x/wk approach avoid the sides (nausea right after the dose, and intense hunger before the next one) and still obtain the same weight loss results. As we've all said a million times, there is no right way for everyone, what works best is what works best for you and that takes some time, journaling, and consistency to figure out (change only one variable at at time and give it some time esp with compounds that have longer t 1/2s). Lastly, you can't take one perspective on something, even if it fits your confirmational bias and run with it. You have to keep an open mind and look at things from 36,000 feet, not ground level. The overall perspective is far more complex, but also more informative relative to making the best decision.

Agreed. To Kyle's credit, he stated that he recommends Reta to his clients for the BG regulation and other benefits, as opposed to its use as a weight loss drug. In fact, a lot of the discussion is use of Reta in a push phase to more efficiently clear BG prior to the next meal to maintain insulin sensitivity in a push phase.

 

[genetic freak]

Agreed. To Kyle's credit, he stated that he recommends Reta to his clients for the BG regulation and other benefits, as opposed to its use as a weight loss drug. In fact, a lot of the discussion is use of Reta in a push phase to more efficiently clear BG prior to the next meal to maintain insulin sensitivity in a push phase.

I prefer it in the growth phase for this reason as well, especially if running 10+ iu of GH. Coupled with SLU and it keeps A1C under 5. The only issue is you have to deal with the bloating. 2-3 g of magnesium before bed and the use of betaine/pepsin and digestive enzymes help a lot.

 

[Massive G]

I am going to start once a week dosing with reta when I return from vacation. Will still start small .5 mg and work up.
I see a lot of negative responses to the video on the boards but you can't really judge a dosing scheme until you try it as every one is different. Plus the manufacturers put a lot of time in defining dosing schemes during development and clinical trials.

 

[DieYoungStrong]

I am going to start once a week dosing with reta when I return from vacation. Will still start small .5 mg and work up.
I see a lot of negative responses to the video on the boards but you can't really judge a dosing scheme until you try it as every one is different. Plus the manufacturers put a lot of time in defining dosing schemes during development and clinical trials.

Very true, but I do believe what TommyGuns was saying has merit. The manufacturers are looking for the simplest, effective dosing schemes that the general population will adhere too. If they could have made GLP's pills work as effectively as the injections - we would have them. They definitely want to find an effective dose with the fewest injections possible.

That doesn't mean there isn't an even better way to do it. And there's guys on this board who would pin 4x a day even if it was only a small advantage over 1x a week haha.