This is data from Bhasin et al. Yes, SHBG does decrease with dosing at and above 300 mg/wk, but if you take the percent free of the total at 25, 50, 125, 300 and 600 mg/wk, you end up with 11.4, 10.5, 9.1, 10.2 and 11.6%, respectively. Really not that much difference and the 25 mg dose and 600 mg dose has the highest % free even though the 600 mg dose produces a lower SHBG. The real SHBG crushers are C-17 orals and SARMs.