SHINE
Friends Remembered
- Oct 11, 2010
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Testosterone administration for heart related problems...
These absracts promote it for insulin sensitivity in men with heart failure and with pulmonary hypertension.
IMO HRT is down right good for you! as 99% of the studies I have seen say the same.
peace.
Eur J Heart Fail. 2006 Jul 5; [Epub ahead of print] Links
The effect of testosterone on insulin sensitivity in men with heart failure.Malkin CJ, Jones TH, Channer KS.
Department of Cardiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, S10 2JF, United Kingdom.
Resistance to insulin occurs in chronic heart failure (CHF) and is related to prognosis. Studies of testosterone in non-(CHF) males suggest that physiological testosterone therapy improves insulin sensitivity. This was a single-blind placebo controlled crossover trial to determine the effect of testosterone replacement on insulin sensitivity in 13 men with moderate to severe CHF (ejection fraction 30.5+/-1.3). The primary outcome was the homeostatic model index (HOMA-IR) of fasting insulin sensitivity and secondary outcomes were body composition as measured by bioelectrical impedance and glucose tolerance to a standard 75 g oral glucose load. Analysis was performed on the delta values with the treatment effect of placebo compared with that of testosterone. At baseline HOMA-IR correlated with measures of body fat [% fat mass (rP=0.84, p=0.0001) and body mass index (rP=0.79, p=0.01)] but not with CHF severity. Testosterone reduced HOMA-IR (-1.9+/-0.8, p=0.03) indicating improved fasting insulin sensitivity. Testosterone also increased total mass (+1.5+/-0.5 kg, p=0.008) and decreased body fat (-0.8+/-0.3%, p=0.02). Testosterone improves fasting insulin sensitivity in men with CHF and may also increase lean body mass, these data suggest a favourable effect of testosterone on an important metabolic component of CHF.
PMID: 16828341 [PubMed - as supplied by publisher]
Curr Vasc Pharmacol. 2006 Jan;4(1):9-15. Links
The influence of sex hormones on pulmonary vascular reactivity: possible vasodilator therapies for the treatment of pulmonary hypertension.Smith AM, Jones RD, Channer KS.
Department of Cardiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, S10 2JF, UK.
Pulmonary hypertension is a rare disease of the pulmonary vasculature defined as a mean pulmonary artery pressure >25 mmHg at rest or 30 mmHg with exercise. Recent therapies such as epoprostenol, bosentan and sildenafil are directed at the arterial vascular bed, causing vasodilatation and reducing pulmonary vascular resistance. However idiopathic pulmonary artery hypertension (IPAH) occurs predominantly in women, with three times the incidence compared to men and this suggests that sex hormones may be involved in the pathogenesis. 17beta -oestradiol is a pulmonary vasodilator, proposed to act via an endothelium-dependant pathway, involving nitric oxide (NO) and has also been shown to alter responses to hypoxia. Progesterone is also a pulmonary vasodilator but differs from 17beta-oestradiol in having endothelial-dependant and independent processes implicated. Interestingly testosterone has been shown to be a vasodilator in both the coronary and pulmonary circulation with a mechanism of action involving calcium channel blockade of the vascular smooth muscle and without endothelial involvement. In clinical trials testosterone confers symptomatic benefits in patients with coronary heart disease and heart failure, acting as a vasodilator. These observations lend support to the notion that testosterone could be a potential treatment for patients with PAH as vasodilator therapy remains the mainstay of treatment. Other potential beneficial effects of testosterone in the pulmonary circulation include immuno-modulation, altering expression of cytokines and an anti-thrombotic action. In this review the influence of sex hormones on the pulmonary vasculature will be discussed, with specific focus on pulmonary hypertension and the potential treatment of this condition.
PMID: 16472172 [PubMed - indexed for MEDLINE]
Endocr Res. 2005;31(4):335-44. Links
The inverse relationship between thoracic aortic intima media thickness and testosterone level.Demirbag R, Yilmaz R, Ulucay A, Unlu D.
Harran University, Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey. [email protected]
BACKGROUND: It is known that testosterone prevents coronary artery disease, and lower testosterone level is a risk factor for ischemic heart disease in men. However, there is no report showing the relationship between testosterone level and severity of thoracic aortic atherosclerosis. AIM: To investigate whether a relationship exists between atherosclerotic thoracic aortic intima media thickness (TAIT) and testosterone level. METHOD: Forty-two male patients (mean age 56 +/- 12 years) without a history of atherosclerotic cardiovascular disease referred for transesophageal echocardiography (TEE) were included. Intima media thickness of aorta was evaluated in each patient by using TEE. Testosterone levels were measured using a commercial kit. Blood chemistry parameters were measured by automated analyzers. The data obtained was evaluated by using correlation analyses and linear regression analysis tests. RESULTS: Mean testosterone values were 507 +/- 209 ng/dl. Testosterone levels showed a negative significant correlation with TAIT (r = -765, p < 0.001). In addition, testosterone levels showed positive correlations with albumin (r = 0.690, p = 0.019) and negative correlations with uric acid (r = -0.630, p < 0.001), HsCRP (r = -0.449, p = 0.003), fibrinogen (r = -0.508, p = 0.001), and white blood cells (r = -0.433, p = 0.005). On the other hand, multiple linear regression analysis showed that TAIT was independently associated with testosterone and uric acid (beta = -0.610, p = 0.002 versus beta = 0.409, p = 0.026 respectively). CONCLUSION: This study indicates that there is an independent relationship between testosterone and TAIT.
J Endocrinol Invest. 2005;28(3 Suppl):32-8. Links
Effects of androgens on the cardiovascular system.Rosano GM, Cornoldi A, Fini M.
Department of Internal Medicine, San Raffaele, Roma, Italy. [email protected]
The evidence that men have a greater incidence of coronary artery disease than women of similar age, together with the fact that android fat distribution is associated with a greater incidence of coronary heart disease, have suggested that high testosterone levels are associated with an increased risk for coronary artery disease. The possible causal role of androgens in the development of cardiovascular disease has not been proven and, to date, there are no epidemiological and pathophysiological evidences to support that an hyper-androgenic state or androgen replacement is associated with cardiovascular disease in both sexes. Clinical studies have suggested that physiological testosterone supplementation in ageing males has a positive effect upon lipid profile. Additional potential protective cardiovascular effects of androgens may be related to their effect upon endothelial function and vasomotor tone. Few data are currently available on the correlation between plasma testosterone levels and coronary artery disease in men. Cross-sectional studies reported either reduced or similar plasma testosterone levels and/or androgens in patients with coronary artery disease as compared to controls without cardiovascular symptoms. Epidemiological studies addressing the importance of androgen levels upon cardiovascular mortality and morbidity have gathered inconclusive results. Prospective studies found no significant association between plasma testosterone and cardiac events in both sexes, while most cross-sectional studies have repetitively found an association between hypotestosteronemia and cardiovascular morbidity. In conclusion, androgens in general and testosterone in particular may have some protective effects on the cardiovascular system through their metabolic and direct effects upon human vasculature.
PMID: 16042358 [PubMed - indexed for MEDLINE]
Pol Merkuriusz Lek. 2005 Mar;18(105):295-7. Links
[Sex hormones, HDL cholesterol and other lipoproteins in older males][Article in Polish]
Barud W, Palusinski R, Piotrowska-Swirszcz A, Ostrowski S, Makaruk B.
Katedra i Klinika Chorob Wewnetrznych Akademii Medycznej w Lublinie. [email protected]
The associations between sex hormones and cardiovascular risk factors in men are controversial. It is well known that testosterone level declines with age and this phenomenon is associated with increased incidence of cardiovascular disease in men. Elevated levels of total cholesterol and LDL cholesterol together with low HDL cholesterol are the important risk factors of coronary heart disease. THE AIM OF STUDY was to investigate the relationships between sex hormones and plasma lipids in aging males. MATERIAL: The study group comprised 107 males over 50 years old. RESULTS: A significant positive correlation was found between testosterone (T) and HDL-cholesterol (r=0.251; p<0.01). Estradiol level was inversely correlated with total cholesterol (r=-0.204; p<0.05). Interestingly, the older age of subjects was associated with increased levels of SHBG (r=0.28; p<0.01) and decreased free testosterone index (T/SHBG) (r=-0.423; p<0.001). CONCLUSION: These data support relationship between sex hormones and plasma lipids and suggest that a low testosterone concentration in aging males may be important in the pathogenesis of atherosclerosis.
PMID: 15997636 [PubMed - indexed for MEDLINE]
These absracts promote it for insulin sensitivity in men with heart failure and with pulmonary hypertension.
IMO HRT is down right good for you! as 99% of the studies I have seen say the same.
peace.
Eur J Heart Fail. 2006 Jul 5; [Epub ahead of print] Links
The effect of testosterone on insulin sensitivity in men with heart failure.Malkin CJ, Jones TH, Channer KS.
Department of Cardiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, S10 2JF, United Kingdom.
Resistance to insulin occurs in chronic heart failure (CHF) and is related to prognosis. Studies of testosterone in non-(CHF) males suggest that physiological testosterone therapy improves insulin sensitivity. This was a single-blind placebo controlled crossover trial to determine the effect of testosterone replacement on insulin sensitivity in 13 men with moderate to severe CHF (ejection fraction 30.5+/-1.3). The primary outcome was the homeostatic model index (HOMA-IR) of fasting insulin sensitivity and secondary outcomes were body composition as measured by bioelectrical impedance and glucose tolerance to a standard 75 g oral glucose load. Analysis was performed on the delta values with the treatment effect of placebo compared with that of testosterone. At baseline HOMA-IR correlated with measures of body fat [% fat mass (rP=0.84, p=0.0001) and body mass index (rP=0.79, p=0.01)] but not with CHF severity. Testosterone reduced HOMA-IR (-1.9+/-0.8, p=0.03) indicating improved fasting insulin sensitivity. Testosterone also increased total mass (+1.5+/-0.5 kg, p=0.008) and decreased body fat (-0.8+/-0.3%, p=0.02). Testosterone improves fasting insulin sensitivity in men with CHF and may also increase lean body mass, these data suggest a favourable effect of testosterone on an important metabolic component of CHF.
PMID: 16828341 [PubMed - as supplied by publisher]
Curr Vasc Pharmacol. 2006 Jan;4(1):9-15. Links
The influence of sex hormones on pulmonary vascular reactivity: possible vasodilator therapies for the treatment of pulmonary hypertension.Smith AM, Jones RD, Channer KS.
Department of Cardiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, S10 2JF, UK.
Pulmonary hypertension is a rare disease of the pulmonary vasculature defined as a mean pulmonary artery pressure >25 mmHg at rest or 30 mmHg with exercise. Recent therapies such as epoprostenol, bosentan and sildenafil are directed at the arterial vascular bed, causing vasodilatation and reducing pulmonary vascular resistance. However idiopathic pulmonary artery hypertension (IPAH) occurs predominantly in women, with three times the incidence compared to men and this suggests that sex hormones may be involved in the pathogenesis. 17beta -oestradiol is a pulmonary vasodilator, proposed to act via an endothelium-dependant pathway, involving nitric oxide (NO) and has also been shown to alter responses to hypoxia. Progesterone is also a pulmonary vasodilator but differs from 17beta-oestradiol in having endothelial-dependant and independent processes implicated. Interestingly testosterone has been shown to be a vasodilator in both the coronary and pulmonary circulation with a mechanism of action involving calcium channel blockade of the vascular smooth muscle and without endothelial involvement. In clinical trials testosterone confers symptomatic benefits in patients with coronary heart disease and heart failure, acting as a vasodilator. These observations lend support to the notion that testosterone could be a potential treatment for patients with PAH as vasodilator therapy remains the mainstay of treatment. Other potential beneficial effects of testosterone in the pulmonary circulation include immuno-modulation, altering expression of cytokines and an anti-thrombotic action. In this review the influence of sex hormones on the pulmonary vasculature will be discussed, with specific focus on pulmonary hypertension and the potential treatment of this condition.
PMID: 16472172 [PubMed - indexed for MEDLINE]
Endocr Res. 2005;31(4):335-44. Links
The inverse relationship between thoracic aortic intima media thickness and testosterone level.Demirbag R, Yilmaz R, Ulucay A, Unlu D.
Harran University, Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey. [email protected]
BACKGROUND: It is known that testosterone prevents coronary artery disease, and lower testosterone level is a risk factor for ischemic heart disease in men. However, there is no report showing the relationship between testosterone level and severity of thoracic aortic atherosclerosis. AIM: To investigate whether a relationship exists between atherosclerotic thoracic aortic intima media thickness (TAIT) and testosterone level. METHOD: Forty-two male patients (mean age 56 +/- 12 years) without a history of atherosclerotic cardiovascular disease referred for transesophageal echocardiography (TEE) were included. Intima media thickness of aorta was evaluated in each patient by using TEE. Testosterone levels were measured using a commercial kit. Blood chemistry parameters were measured by automated analyzers. The data obtained was evaluated by using correlation analyses and linear regression analysis tests. RESULTS: Mean testosterone values were 507 +/- 209 ng/dl. Testosterone levels showed a negative significant correlation with TAIT (r = -765, p < 0.001). In addition, testosterone levels showed positive correlations with albumin (r = 0.690, p = 0.019) and negative correlations with uric acid (r = -0.630, p < 0.001), HsCRP (r = -0.449, p = 0.003), fibrinogen (r = -0.508, p = 0.001), and white blood cells (r = -0.433, p = 0.005). On the other hand, multiple linear regression analysis showed that TAIT was independently associated with testosterone and uric acid (beta = -0.610, p = 0.002 versus beta = 0.409, p = 0.026 respectively). CONCLUSION: This study indicates that there is an independent relationship between testosterone and TAIT.
J Endocrinol Invest. 2005;28(3 Suppl):32-8. Links
Effects of androgens on the cardiovascular system.Rosano GM, Cornoldi A, Fini M.
Department of Internal Medicine, San Raffaele, Roma, Italy. [email protected]
The evidence that men have a greater incidence of coronary artery disease than women of similar age, together with the fact that android fat distribution is associated with a greater incidence of coronary heart disease, have suggested that high testosterone levels are associated with an increased risk for coronary artery disease. The possible causal role of androgens in the development of cardiovascular disease has not been proven and, to date, there are no epidemiological and pathophysiological evidences to support that an hyper-androgenic state or androgen replacement is associated with cardiovascular disease in both sexes. Clinical studies have suggested that physiological testosterone supplementation in ageing males has a positive effect upon lipid profile. Additional potential protective cardiovascular effects of androgens may be related to their effect upon endothelial function and vasomotor tone. Few data are currently available on the correlation between plasma testosterone levels and coronary artery disease in men. Cross-sectional studies reported either reduced or similar plasma testosterone levels and/or androgens in patients with coronary artery disease as compared to controls without cardiovascular symptoms. Epidemiological studies addressing the importance of androgen levels upon cardiovascular mortality and morbidity have gathered inconclusive results. Prospective studies found no significant association between plasma testosterone and cardiac events in both sexes, while most cross-sectional studies have repetitively found an association between hypotestosteronemia and cardiovascular morbidity. In conclusion, androgens in general and testosterone in particular may have some protective effects on the cardiovascular system through their metabolic and direct effects upon human vasculature.
PMID: 16042358 [PubMed - indexed for MEDLINE]
Pol Merkuriusz Lek. 2005 Mar;18(105):295-7. Links
[Sex hormones, HDL cholesterol and other lipoproteins in older males][Article in Polish]
Barud W, Palusinski R, Piotrowska-Swirszcz A, Ostrowski S, Makaruk B.
Katedra i Klinika Chorob Wewnetrznych Akademii Medycznej w Lublinie. [email protected]
The associations between sex hormones and cardiovascular risk factors in men are controversial. It is well known that testosterone level declines with age and this phenomenon is associated with increased incidence of cardiovascular disease in men. Elevated levels of total cholesterol and LDL cholesterol together with low HDL cholesterol are the important risk factors of coronary heart disease. THE AIM OF STUDY was to investigate the relationships between sex hormones and plasma lipids in aging males. MATERIAL: The study group comprised 107 males over 50 years old. RESULTS: A significant positive correlation was found between testosterone (T) and HDL-cholesterol (r=0.251; p<0.01). Estradiol level was inversely correlated with total cholesterol (r=-0.204; p<0.05). Interestingly, the older age of subjects was associated with increased levels of SHBG (r=0.28; p<0.01) and decreased free testosterone index (T/SHBG) (r=-0.423; p<0.001). CONCLUSION: These data support relationship between sex hormones and plasma lipids and suggest that a low testosterone concentration in aging males may be important in the pathogenesis of atherosclerosis.
PMID: 15997636 [PubMed - indexed for MEDLINE]
