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ValeTudo8080

ValeTudo8080

VIP Member
Aug 31, 2011
424
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I think you need to binge drink a few days in a row and then get tested....it should crash your test enough to get the script!
 
DieYoungStrong

DieYoungStrong

VIP Member
May 27, 2013
1,152
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that's it bro. Genetic makeup has as much or more to do with lipids profiles then your


My hdl was in that range as well and i was eating what we consider to be a stellar diet. the balance of my lipid profile was excellent but the ratio's of overall lipid heath needed the HDL # over 40 (pretty sure).

Eventually after years of eating clean (sick of it) i expanded my diet to include things I'd not eaten often. Fries, sweets, fried food ... all in moderation but more.

I was very curious how my lipid profile would change.

It improved. HDL was low 40's. Ratio was perfect overall in the high 130's - 40's

Ate the same for 2 more years and the second blood draw post diet adjustment improved again!

So what did that tell me? Cutting out some foods entirely ~vs~ moderation of overall diet worked better for me.

Point being .. maybe expand your diet .. change things up for a while and retest.

Pretty sure I still have copies around..

I'm 40 and have tried a lot of different diets over the years - never has any meaningful effect on it. It's a genetic thing. My father and uncles all have similar lipid profiles, and none of them ever ran any juice or were hard core into lifting.

I am cutting out orals now that I've hit 40 as they really jack up my profile for a loooong time, and I'm focusing more on being healthy then big. Small blast or two a year will be it for me.
 
O

OldPLer

Senior Member
Nov 29, 2010
165
32
I have been having high creatinine levels 1.5 and if it doesn’t go down she wants me to go to nephrologist to get kidneys checked. Anyone else have high creatinine levels.
 
Bigtex

Bigtex

VIP Member
Aug 14, 2012
587
891
I have been having high creatinine levels 1.5 and if it doesn’t go down she wants me to go to nephrologist to get kidneys checked. Anyone else have high creatinine levels.

Does your doctor know a high protein diet can bring about high creatinine levels? Taking creatine supplements can also cause high creatinine levels, both screw up the eGRF readings. High intensity weight training and muscle mass also does the same. Creatinine is a normal product of muscle metabolism (breakdown) and is eliminated through the urine. So the more muscle mass you have and the more intensely you train the more more muscle breakdown you will have, Thus creatinine levels will be higher. There is creatine in all protein and of course the creatine supplement. It breaks down to creatinine eventually. So creatinine is a waste product from the digestion of dietary protein and the normal breakdown of muscle tissue. However, creatinine levels can be affected by several other factors, including diet (high protein),muscle mass, malnutrition and other chronic illnesses.

Here is mine:
2015
Creatinine - 1.68
eGFR - 43
2020
Creatinine - 1.32
eGFR - 57

My weight from 2017 changed from 270 to 233 and my training is not nearly as intense today and obviously don't have near the muscle mass. I also took a protein shake and creatine the morning I did blood testing in 2020.

I will look for supporting studies but I just had to go through the same thing with my cardiologist. I actually found blood work from 6 years ago where I was heavier and training harder and my creatinine and eGRF levels were much better today than then. If this was kidney disease it would be worse.

There is supposedly a new creatinine-cystatin equation that is being used now that is much more accurate and is less altered by other medical conditions and issues.
 
rawdeal

rawdeal

TID Board Of Directors
Nov 29, 2013
2,854
1,674
. . . There is supposedly a new creatinine-cystatin equation that is being used now that is much more accurate and is less altered by other medical conditions and issues . . .
There is a guy called "Steroid Doc" on youtube who cautions against all the different bad things the bodybuilding lifestyle can do to us in multiple episodes. He said all the stuff about kidneys ... and kidney tests ... that is in the complete post from Bigtex above. BUT, he also mentioned "cystatin" as being more indicative of what's really going on with our kidneys than the standard tests are. I got the impression this may be a test most doctors wouldn't order for you unless you coached them through "modern medicine" a bit.
 
Bigtex

Bigtex

VIP Member
Aug 14, 2012
587
891
Thanks rawdeal! When I suggested this to my cardiologist he still insisted I see a kidney specialist. I just flat out pulled rank on him and said NO. Hell, I am the one paying the bills here.:)
 
Bigtex

Bigtex

VIP Member
Aug 14, 2012
587
891
OK, I managed to find some supporting research. First problem with the eGFR is muscle mass.

The use of creatine supplements and high protein diets

Lydia Williamson, David New. How the use of creatine supplements can elevate serum creatinine in the absence of underlying kidney pathology. BMJ Case Rep. 2014 Sep 19;2014.

This report describes a case in which the consumption of the bodybuilding supplement creatine ethyl ester resulted in raised serum creatinine in the absence of true underlying kidney pathology. The abnormalities reversed after discontinuation of the supplement. A case of pseudo renal failure was recognised and kidney function was concluded to be normal.

As rawdeal posted

Alessandra Calábria Baxmann, Marion Souza Ahmed, Natália Cristina Marques, Viviane Barcellos Menon, Aparecido Bernardo Pereira, Gianna Mastroianni Kirsztajn and Ita Pfeferman Heilberg. Influence of Muscle Mass and Physical Activity on Serum and Urinary Creatinine and Serum Cystatin C. Clinical Journal of the American Society of Nephrology. Vol. 3, Issue 2. March 2008.

Conclusions: Cystatin C may represent a more adequate alternative to assess renal function in individuals with higher muscle mass when mild kidney impairment is suspected.

Forbes GB, Bruining GJ. Urinary creatinine excretion and lean body mass. Am J Clin Nutr 1976;29:1359-1366.

Creatinine is produced nonenzymatically in the skeletal muscle, and the amount of creatinine production, and therefore the 24 h excretion of creatinine, is directly related to muscle mass.

Cystatin C may be preferable to creatinine to assess kidney function in individuals with higher muscle mass. An increase in muscle mass would be expected to result in an increase in serum creatinine level in the absence of change in kidney function. Because serum creatinine is derived from the metabolism of creatinine produced by muscle, a significant increase in muscle mass would be expected to increase serum creatinine. An elevation in serum creatinine could also occur with creatine supplements, which he is not taking. This patient has a normal urinalysis and no proteinuria, all of which indicate no evidence of underlying kidney disease. Cystatin C, which is cleared by the kidney, is produced by all nucleated cells; therefore, levels are less dependent on muscle mass. Cystatin C can also be used for more accurate glomerular filtration rate estimation in these patients as a component of the Chronic Kidney Disease Epidemiology Collaboration equation.

Creatinine is produced nonenzymatically in the skeletal muscle, and the amount of creatinine production, and therefore the 24 h excretion of creatinine, is directly related to muscle mass.

So I would say as rawdeal has educate your doctor about this and ask for the Cystatin C test instead of eGFR. If he won't do that just refuse to see a specialist and monitor your eGFR in the future.
 
DungeonDweller

DungeonDweller

VIP Member
Mar 21, 2017
1,043
757
My creatinine is always slightly high. I've per year been at 1.29 1,29 1.24 and now 1.35
Doctor just this morning said "I want to watch that."
 
rawdeal

rawdeal

TID Board Of Directors
Nov 29, 2013
2,854
1,674
. . . As rawdeal posted . . .
That rawdeal is a clever bastard. When he quoted Bigtex above, he obviously knew that if he could lure Bigtex out of the woods the board would get a much better version of the talk about this relatively unknown Cystatin test. Mission accomplished ;)
 
O

OldPLer

Senior Member
Nov 29, 2010
165
32
I will look at this more. I am also refusing to go to nephrologist but Cystatin sounds like a good approach. I told her that is I was black my Egfr would be much better because the formula assumes that black male would have more muscle mass than white male. What the hell
Thanks for information
 
rawdeal

rawdeal

TID Board Of Directors
Nov 29, 2013
2,854
1,674
I will look at this more. I am also refusing to go to nephrologist but Cystatin sounds like a good approach. I told her that is I was black my Egfr would be much better because the formula assumes that black male would have more muscle mass than white male. What the hell
Thanks for information
Is that what that's all about on the PrivateMD lab reports I use in lieu of doctors as much as I can ... wtf? I always wondered why they say the sample you submit means 2 different eGFR's depending on if you're Black or White. I guess what they're doing, sort of, is acknowledging what others here have said ... that muscle mass is one factor in calculating eGFR, and that this commonly used test may not be telling us what we think it is about our true kidney health.

Balls to that ... now I need to find out if that Cystatin C test reports a real number vs. a calculation of various other numbers. I'm hoping it's a simple, basic number, like hematocrit or glucose or HDL, and not a calculation that can be misleading, like eGFR. I notice my reports on PSA like to invoke calculations when they get around to saying what % chance of cancer I have, and I always wind up a little confused as to good news or bad news? Phooey.
 
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