Jun 16, 2016 Nope. It dissipates very quickly. I've subQ 3/4ml before without issue and there is a little lump for a few hours then spreads out and dissipates completely in 24 hours. Most of the time the inject site is not noticable within 2 hours meaning no lump. I've been doing subQ for TRT for 10 years. I don't feel any pain except when I go to close to the naval which I don't do anymore. I pin anywhere on my thighs and abdomen except for the area 1.5 inches around the naval. Blood work is excellent and supposedly there is less conversion to E2 subQ. No scar tissue in muscles whatsoever. What is there not to like about SubQ. My routine .57ml e4d currently. I use 27g slins and they fill just fine. 30g on up is not recommend.