SLU-PP-332

[Mike_RN]

If you already have a heart block than a prolonged QT might cause lightheadedness or syncopal episodes when training or any other exertion.

 

[Wilson6]

If you already have a heart block than a prolonged QT might cause lightheadedness or syncopal episodes when training or any other exertion.

I was also thinking torsades, that would be a little more problematic. Given all the guys out there with likely pathological/physiological LVH, why take a chance.

 

[Wilson6]

Would on of those kardiamobile devices work?

If the device gives a clean QT on a grid, it is fairly easy to measure, there are several calculators and how to for cardiologists on line. I'm prone to NSVTs because of a mild HCM non-obstructive, so I have to be careful.

 

[bigdbag]

I'm new here but how the hell are you people finding out about research chemicals only trialed on mice? Only recently became interested in lifting for lifting's sake, bodybuilding, etc. Ya'll are crazy.

 

[rawdeal]

I'm new here but how the hell are you people finding out about research chemicals only trialed on mice? Only recently became interested in lifting for lifting's sake, bodybuilding, etc. Ya'll are crazy.

True that. We DO discuss bodybuilding and bench presses and biceps and stuff, but mostly from some very experienced folks.

Welcome to TID, we may take a bit of getting used to.

 

[Cohiba]

I ran the 800mcg for about 3 weeks and didn't notice anything. I went up to 1600mcg am dosed the past week.

I do feel better in the gym, but I also changed some other stuff I was running that I think was bogging me down. I have no idea if it's due to the SLU.

I know chatgpt can be bullshit but I asked it about dosing this stuff for humans based on all the existing studies, and it is saying the dose should be way higher than what most people are taking here, like 20-50mg a day.

 

[Lil Ed]

Than again ChatGPT is not aware of private studies done on many animals Including exotic ones and yes also humans, some of them being Olympic athletes by private groups and that alone could be a good reason to wipe your ass with ChatGPT opinions. Its basically as good as your own.

We have already had one long time member here that is trusted,.... regret higher doses, in his own words.
.....................................................................................................................
Copy and pasted below....

Its a brave new world.. we cant really monitor Sub Quantum Levels but we know they are in effect as we can perform measurements in Sub Atomic Particle level..
certain techniques in physics and medical science allow us to indirectly study or detect subatomic particles or their effects in humans......and its right above Quantum.. lots of cool things to learn and take part in that could benefit us and those we care about.

just getting info/Data now on why animals can do larger doses of Slu-pp-332 seems we do so much with Polypharmacy that we are improving mV of Mitochondria.. we take Test, rHGH, Supps, all drive up Mitochondria membrane function.

mV -> (millivolts) of mitochondria refers to the mitochondrial membrane potential (ΔΨm), which is the electrical potential difference across the inner mitochondrial membrane. This potential is typically measured in millivolts and is a key indicator of mitochondrial health and function.

Slu is far from new, Early 2000's it was created at Saint Louis University.. high doses have been performed on humans in private groups and many many animals.

Horses can handle 100mg, as cats and dogs only in mcg..Largest variables on exotic species
monitoring of
Tachycardic
Nausea
Black out ...<- bad
Cell death <- Guaranteed blown out walls, destroyed healthy Mitochondria as sure as the Devils dick is red.

Rare few amount of humans could handle 1 to 10mg, this would increase if we were also not adjusting mV as much as we do with our daily activities and supplementation.

GLP large doses damaging GLP receptors... and now how to repair and improve them. how to get them to work for none responders. how to use them and optimize them with GLP rotation and micro dosing. in Layman terms you can smack me all day and I can take it.. hit me with a sledge Hammer, and you potentially kill me. makes sense right? poor little fucking receptors getting F in the ass by Chase Irons.. telling you to take more stupid, you need more... 2mg doesn't work anymore and he needs a new Car,,, sorry I meant to say another happy client... lmfao

Stem cell therapy isn't cheap, neither is SS31 for the cheaper repair of damaged GLP receptors.

 

[Lizard King]

Does someone want to translate what the mad scientist just posted?

 

[genetic freak]

I ran the 800mcg for about 3 weeks and didn't notice anything. I went up to 1600mcg am dosed the past week.

I do feel better in the gym, but I also changed some other stuff I was running that I think was bogging me down. I have no idea if it's due to the SLU.

I know chatgpt can be bullshit but I asked it about dosing this stuff for humans based on all the existing studies, and it is saying the dose should be way higher than what most people are taking here, like 20-50mg a day.

I went up to 20 mg a day. I can't say that I liked it all that much. I never really felt much of a stimulant feeling up to 1.5 mg 3x a day, but once I want to 5 mg 4x day, I felt overstimulated to the point I felt like I was starting to suffer from adrenal fatigue. Maybe, if I would have worked my way up instead of jumping from 4.5 to 20 mg, I would have felt fine, but I decided to drop back down to 4.5 mg and all was good. I have considered giving it another go, since there are many who are using 100-400 mg a day and reporting crazy benefits.

 

[tommyguns2]

I've heard some crazy stuff about somebody running it up to 400mg in a day. This is what I got from AI on dosing this stuff too high.


At moderate doses, uncouplers can improve efficiency by reducing ROS (reactive oxygen species) buildup, increasing metabolic flexibility, and promoting fat oxidation. But if you push the dose too high, the effects shift from “therapeutic” to toxic:

---

Potential negative mitochondrial effects at very high doses of SLU-PP-332​

1. Excessive uncoupling → ATP depletion
   • Proton gradients across the mitochondrial inner membrane are dissipated too strongly.
   • ATP synthase can’t keep up → cellular ATP levels crash.
   • Energy-hungry tissues (muscle, brain, heart, liver) are most at risk.
2. Mitochondrial stress and damage
   • Over-uncoupling forces mitochondria to burn through substrates (glucose, fatty acids) at extreme rates.
   • This can lead to incomplete oxidation, accumulation of intermediates, and mitochondrial dysfunction.
3. Oxidative stress
   • Mild uncoupling reduces ROS.
   • But extreme uncoupling can paradoxically increase ROS, as the electron transport chain runs “flat out” in a futile attempt to maintain membrane potential.
4. Cell death pathways
   • ATP depletion plus ROS can trigger apoptosis or necrosis.
   • In animal studies with strong uncouplers, liver and muscle cells are especially vulnerable.
5. Systemic risk (beyond mitochondria)
   • Hyperthermia: all that wasted energy dissipates as heat (similar risk as with DNP overdose).
   • Organ failure: particularly liver and kidney injury due to high metabolic stress.
   • Cardiac arrhythmia: the heart is highly dependent on ATP, so uncoupling can destabilize rhythm under stress.

Summary:
At very high doses, SLU-PP-332 could overwhelm mitochondria, leading to ATP collapse, oxidative stress, mitochondrial injury, and ultimately cell death — with systemic consequences like overheating, organ damage, and cardiovascular instability.


So while SLU-PP-332 was designed to be safer than older uncouplers like DNP or BAM15, the same fundamental risks apply if pushed too far.

 

[tommyguns2]

Until we know more about this compound, I recommend people staying less than 5mg/day, and preferably less than 2mg/day.

Some people seem to really respond well to this compound, while others feel nothing. My response at 500mcg/day was muted, and I've upped it to 500mcg 3x/day. No negative effects, but it's not DNP, that's for darn sure.

 

[genetic freak]

I've heard some crazy stuff about somebody running it up to 400mg in a day. This is what I got from AI on dosing this stuff too high.


At moderate doses, uncouplers can improve efficiency by reducing ROS (reactive oxygen species) buildup, increasing metabolic flexibility, and promoting fat oxidation. But if you push the dose too high, the effects shift from “therapeutic” to toxic:

---

Potential negative mitochondrial effects at very high doses of SLU-PP-332​

1. Excessive uncoupling → ATP depletion
   • Proton gradients across the mitochondrial inner membrane are dissipated too strongly.
   • ATP synthase can’t keep up → cellular ATP levels crash.
   • Energy-hungry tissues (muscle, brain, heart, liver) are most at risk.
2. Mitochondrial stress and damage
   • Over-uncoupling forces mitochondria to burn through substrates (glucose, fatty acids) at extreme rates.
   • This can lead to incomplete oxidation, accumulation of intermediates, and mitochondrial dysfunction.
3. Oxidative stress
   • Mild uncoupling reduces ROS.
   • But extreme uncoupling can paradoxically increase ROS, as the electron transport chain runs “flat out” in a futile attempt to maintain membrane potential.
4. Cell death pathways
   • ATP depletion plus ROS can trigger apoptosis or necrosis.
   • In animal studies with strong uncouplers, liver and muscle cells are especially vulnerable.
5. Systemic risk (beyond mitochondria)
   • Hyperthermia: all that wasted energy dissipates as heat (similar risk as with DNP overdose).
   • Organ failure: particularly liver and kidney injury due to high metabolic stress.
   • Cardiac arrhythmia: the heart is highly dependent on ATP, so uncoupling can destabilize rhythm under stress.

Summary:
At very high doses, SLU-PP-332 could overwhelm mitochondria, leading to ATP collapse, oxidative stress, mitochondrial injury, and ultimately cell death — with systemic consequences like overheating, organ damage, and cardiovascular instability.


So while SLU-PP-332 was designed to be safer than older uncouplers like DNP or BAM15, the same fundamental risks apply if pushed too far.

This makes a lot of sense, as those running the super high doses are stating it feels a lot like a moderate DNP dose without the heat.