SGLT2's vs Metformin

[Tuffoldman]

Similar results but different action anyone using SGLT2's?

I find a lot of information on it but not much information on dosage or where to get my hands on it.

 

[J2048b]

Any india pharma… carries these…

 

[genetic freak]

Per Jardiance's insert, it comes in either a 10 or 25 mg dose to be taken once per day in the morning.

 

[myosin]

For renal and/or cardio-protection, 10-12.5mg (25mg tab in half) and you'll still get some blood sugar lowering with that... but if more for blood sugar, 25mg

 

[J2048b]

A lot of it depends on ur blood work tho as well… im hoping taking both will help my glucose issue… so we shall see when i get to that level

 

[Tuffoldman]

The only downside I see is the possibility of UTIs which would be, my guess, is the excretion of sugars in the urine which is where most UTIs come from. UTI Crystal build up in the urinary tract create bacteria and cause uti's. E coli is the most common UTI infection. I take D-mannose 500 mg twice a day which from my understanding is a polysaccharide which is supposed to help eliminate the crystals from collecting in the urinary tract and lower the chances of getting uti's

I currently take metformin extended release 1000 mg every night before bed. From what I'm reading SGLT2 is better at eliminating glucose out of the bloodstream is more efficient than metformin. Anyone's thought on that? Anybody using either or both? My glucose levels are always within the normal range but for some reason I've always been slightly elevated then what I would consider normal. A1C is always fine. My thinking is lower blood sugar would equate to less stored body fat. Now the downside would be less glycogen in the muscles but that may be a stretch.

Always open for thoughts

 

[myosin]

The only downside I see is the possibility of UTIs which would be, my guess, is the excretion of sugars in the urine which is where most UTIs come from. UTI Crystal build up in the urinary tract create bacteria and cause uti's. E coli is the most common UTI infection. I take D-mannose 500 mg twice a day which from my understanding is a polysaccharide which is supposed to help eliminate the crystals from collecting in the urinary tract and lower the chances of getting uti's

I currently take metformin extended release 1000 mg every night before bed. From what I'm reading SGLT2 is better at eliminating glucose out of the bloodstream is more efficient than metformin. Anyone's thought on that? Anybody using either or both? My glucose levels are always within the normal range but for some reason I've always been slightly elevated then what I would consider normal. A1C is always fine. My thinking is lower blood sugar would equate to less stored body fat. Now the downside would be less glycogen in the muscles but that may be a stretch.

Always open for thoughts

The UTI is overblown and if anything in women more than men. Its also more a possibility in the less mobile who are more likely to hold their urine for prolonged amount of time.

While some studies show a higher incidence of UTIs in patients taking Jardiance and other SGLT2 inhibitors, others have found no significant difference. The FDAhas issued a warning about serious UTIs and advises patients to contact their doctor at the first sign

 

[genetic freak]

The only downside I see is the possibility of UTIs which would be, my guess, is the excretion of sugars in the urine which is where most UTIs come from. UTI Crystal build up in the urinary tract create bacteria and cause uti's. E coli is the most common UTI infection. I take D-mannose 500 mg twice a day which from my understanding is a polysaccharide which is supposed to help eliminate the crystals from collecting in the urinary tract and lower the chances of getting uti's

I currently take metformin extended release 1000 mg every night before bed. From what I'm reading SGLT2 is better at eliminating glucose out of the bloodstream is more efficient than metformin. Anyone's thought on that? Anybody using either or both? My glucose levels are always within the normal range but for some reason I've always been slightly elevated then what I would consider normal. A1C is always fine. My thinking is lower blood sugar would equate to less stored body fat. Now the downside would be less glycogen in the muscles but that may be a stretch.

Always open for thoughts

UTIs are possible, but it will really come down to how many carbs you are consuming. For example, I just tried the fruit fast, had my wife try and several clients. Every single one of us ended up with UTI from it. Just too much sugar.

 

[Tuffoldman]

UTIs are possible, but it will really come down to how many carbs you are consuming. For example, I just tried the fruit fast, had my wife try and several clients. Every single one of us ended up with UTI from it. Just too much sugar.

I guess in a way that does make sense because UTIs are generally triggered, from what I've read, is sugar in the urine and then getting in the urinary tract and crystals catching and then forming the infection. I'm sure I'm oversimplifying that but I believe that's what I've read in the past. More sugar in your diet would make sense that it would cause a higher chance of utis. Taking that drug that I'm talking about since it pulls more blood sugar through the kidneys and eliminates it there would be a higher chance. Doing some more research today it says taking higher doses of vitamin c and taking d-mannanose at 1 to 2 g 2 to 3 times a day will almost eliminate that issue. I'm curious on how that would affect overall weight and body composition if you can eliminate sugar out of your system faster.

I like to experiment a lot and just try different compounds and see how they affect me and my wife personally. She is lean even more lean than I am she Burns off a lot of calories from running marathons yet she retains a fair amount of muscle.

Always looking for an edge but even more so it's showing that it's able to protect your kidneys and there is a possibility of lowering the chances of Alzheimer's and some other diseases so that is more of a Plus on my side.

 

[genetic freak]

Anything that helps with the processing or disposal of glucose is going to improve insulin sensitivity, which should make you leaner or provide you the opportunity to eat more food and partition the food properly.

One thing you do have to be concerned about when compounding GDA's is the possibility of hypoglycemia. For me, using reta, SLU and metformin or berberine, I have a fasting glucose level below 70. Sometimes it gets down into the 50's without any symptoms of hypoglycemia. This is actually not a good thing, as the alarm for critically low is not present until it is nearly too late.