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VIP Member
Mar 17, 2011
If you need to kill your appetite to drop a little weight holy cow try semaglutide. It makes phentermine obsolete in my opinion. Half a mg to start and I’m lucky to get more than a handful of food down. It’s super important that you eat very clean healthy food also because it will give you terrible persistent indigestion if not. Id start with a lower dose if I was advising someone I dealt with nausea the first night. Once a week is enough after day 2 it kicks in hard and goes strong for the week. Anyone else try it?
My wife is running this. She has dropped 17 lbs in 2 months without any effort. She does try to eat right. But she gets full before the entre. So far, no side effects for her.


VIP Member
Dec 17, 2019
What is the dosage protocol for Retatrutide?
The lower effective dose seems to be total of 1 or 2 mg/wk without GLP-1 GI sides but still effective. Starting 0.25 mg twice a week, then slowly ramping up to working dose. First ramp can be a couple weeks of there is no effect at 0.25 mg/2 x/wk, then minimum 4 weeks. The studies go much higher per week than this but clients using RETA find that 2 mg esp when combined with an androgen and/or GH is plenty for a synergistic effect and no GI sides. The effects are more subtle and take time, but RETA seems to be much better than any of the other GLP-1s out there. I would think though, at a high enough dose it will cause GLP-1 sides


VIP Member
Oct 30, 2022
Just doing once a week. I should have started at 1/4 mg dose not a half. I would bet 1/4 mg would be just as effective. The sides aren’t bad just have to be mindful of what you eat. I take medicine for acid reflux and it does not help.
It’s the constipation you should be worrying about lol. Yes. I’ve tried it. What I found is that if I take one “higher” dose once a week I’m not hungry at all but that’s because I’m constipated to all hell. If I take same dose split in two for the week I don’t get as constipated but also don’t get as good appetite suppression. It’s almost like you need to take a weekly dose and then a bunch of laxatives right before next dose to get the most out of it. The constipation got old. Let us know how it dose for you.


VIP Member
Oct 30, 2022
Thought about trying it for me and my wife to drop a few lbs before going to the keys but heart burn sounds like a no deal for me
Didn’t have that issue personally. Wife didn’t either.


VIP Member
Oct 30, 2022
I've consider doing the every 2 to 3 nights and see what changes I'm going to try and tough it out until my next blood work in 3 months to see if there's any change one way or the other. At that point I'll probably go ahead if I have to start making some adjustments to my acid reflux regimen so to speak. I found that Ginger root helps a lot. If it gets really bad I do some baking soda but I have to be careful of that because I have high blood pressure and extra sodium is definitely not good for me.

I have dealt with heartburn my whole life honestly I remember even as a teenager having to eat rolaids but I also grew up in a very traumatic environment which I'm sure probably did not help any. Just sucks to have to be careful what I eat some things are way worse acidic foods make it worse spicy foods make it worse but I can have oatmeal and get terrible heartburn it's ridiculous.

I'm going through two more blood donations so in about 120 days I'm going to retest my hematocrit was way up I hadn't given blood in about a year and I'm making some changes my cholesterol was off a bit but that was due to some sloppy eating. That's all back on track and has been since my blood work. I like to see those numbers look a lot better.

I definitely appreciate the feedback. I think we're all going through the same thing as we age things change and we need as much information as we can get to make better choices
Just be careful what you eat because Dusty Hanshaw tore his esophagus eating a steak because he let his acid reflux go and it thinned his esophagus wall lining. Maybe start using astragalus to counter the kidney sides from the medicine. Vitamin shop brand is the go to that’s recommended by Dante. 6000mg Ed. It’s a lot of pills but works.


Senior Moderators
Staff Member
Sep 21, 2011


July 8, 2024

Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity​

Patricia J. Rodriguez, PhD1; Brianna M. Goodwin Cartwright, MS1; Samuel Gratzl, PhD1; et alRajdeep Brar, MD1; Charlotte Baker, DrPH1; Ty J. Gluckman, MD2; Nicholas L. Stucky, MD1

Author Affiliations Article Information

JAMA Intern Med. Published online July 8, 2024. doi:10.1001/jamainternmed.2024.2525

Key Points
Question How does weight loss differ between patients receiving tirzepatide compared with semaglutide among a clinical population of adults with overweight or obesity?

Findings In this cohort study of 18 386 propensity-score matched patients initiating tirzepatide or semaglutide labeled for type 2 diabetes, discontinuation was common; most achieved weight loss of 5% or greater within 1 year of treatment.

Meaning Although most adults with overweight or obesity experienced 5% or greater weight loss with treatment, the benefit was greater with tirzepatide.

Importance Although tirzepatide and semaglutide were shown to reduce weight in randomized clinical trials, data from head-to-head comparisons in populations with overweight or obesity are not yet available.

Objective To compare on-treatment weight loss and rates of gastrointestinal adverse events (AEs) among adults with overweight or obesity receiving tirzepatide or semaglutide labeled for type 2 diabetes (T2D) in a clinical setting.

Design, Setting, and Participants In this cohort study, adults with overweight or obesity receiving semaglutide or tirzepatide between May 2022 and September 2023 were identified using electronic health record (EHR) data linked to dispensing information from a collective of US health care systems. On-treatment weight outcomes through November 3, 2023, were assessed. Adults with overweight or obesity and regular care in the year before initiation, no prior glucagon-like peptide 1 receptor agonist receptor agonist use, a prescription within 60 days prior to initiation, and an available baseline weight were identified. The analysis was completed on April 3, 2024.

Exposures Tirzepatide or semaglutide in formulations labeled for T2D, on or off label.

Main Outcomes and Measures On-treatment weight change in a propensity score–matched population, assessed as hazard of achieving 5% or greater, 10% or greater, and 15% or greater weight loss, and percentage change in weight at 3, 6, and 12 months. Hazards of gastrointestinal AEs were compared.

Results Among 41 222 adults meeting the study criteria (semaglutide, 32 029; tirzepatide, 9193), 18 386 remained after propensity score matching. The mean (SD) age was 52.0 (12.9) years, 12 970 were female (70.5%), 14 182 were white (77.1%), 2171 Black (11.8%), 354 Asian (1.9%), 1679 were of other or unknown race, and 9563 (52.0%) had T2D. The mean (SD) baseline weight was 110 (25.8) kg. Follow-up was ended by discontinuation for 5140 patients (55.9%) receiving tirzepatide and 4823 (52.5%) receiving semaglutide. Patients receiving tirzepatide were significantly more likely to achieve weight loss (≥5%; hazard ratio
, 1.76, 95% CI, 1.68, 1.84; ≥10%; HR, 2.54; 95% CI, 2.37, 2.73; and ≥15%; HR, 3.24; 95% CI, 2.91, 3.61). On-treatment changes in weight were larger for patients receiving tirzepatide at 3 months (difference, −2.4%; 95% CI −2.5% to −2.2%), 6 months (difference, −4.3%; 95% CI, −4.7% to −4.0%), and 12 months (difference, −6.9%; 95% CI, −7.9% to −5.8%). Rates of gastrointestinal AEs were similar between groups.

Conclusions and Relevance In this population of adults with overweight or obesity, use of tirzepatide was associated with significantly greater weight loss than semaglutide. Future study is needed to understand differences in other important outcomes.
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