Semaglutide

[searay]

I’ve used .5 mg week one & two. Feel like i’m on the edge of nausea for most of the week and it seems like just driving past a wing place gives me heartburn. I do have a hiatal hernia so that might be why. Definitely killing the appetite though.

I would back off to .25wk and see if that works with out the nausea.

 

[ExtremeVet2]

I would back off to .25wk and see if that works with out the nausea.

Definitely gonna try that. Next week I’m dropping to .25

 

[Wilson6]

Definitely gonna try that. Next week I’m dropping to .25

Unless the dosing is pre-measured, try splitting the dose, M and R for example. See if that helps the nausea, with the lower dose.

 

[Wallyd]

Unless the dosing is pre-measured, try splitting the dose, M and R for example. See if that helps the nausea, with the lower dose.

My gal has started splitting her dose into 2x per week & it has helped with nausea.

 

[jipped genes]

I've tried the semaglutide at low doses, and while not magic, it absolutely helped me reduce my calories without feeling like I'm starving. That's a huge plus, IMO.

I ran it at:
0.25mg/wk for weeks 1-4
0.5mg/wk for weeks 5-8
and then discontinued. No discomfort. Was still ready to eat at my regularly scheduled meals, but would feel full a bit earlier than normal, so I ate less. I think it's another great tool to have in your toolbox.

Tommy, did you get the heartburn with the low dose? I am doing OK with my macros and maintaining but I am always STARVING and it sucks to always be hungry.

 

[tommyguns2]

Tommy, did you get the heartburn with the low dose? I am doing OK with my macros and maintaining but I am always STARVING and it sucks to always be hungry.

no issues with heartburn at all. I don't usually have heartburn issues, but sometimes I can get heartburn when taking orals.

 

[ExtremeVet2]

The nausea and heartburn are gone. Dropping it worked. Dropped it to .25 and will bump it up next week. I’ll split the .5 Monday & Thursday. Hopefully the heartburn won’t come back.

 

[Wallyd]

The nausea and heartburn are gone. Dropping it worked. Dropped it to .25 and will bump it up next week. I’ll split the .5 Monday & Thursday. Hopefully the heartburn won’t come back.

How many weeks have you been running it at .25?

 

[Wallyd]

Recommended schedule.

 

[MR. BMJ]

Got behind on posting the research over the past year....will try to pick it back up for this thread
************************************************************************************************

Efficacy and Safety of Semaglutide in Weight Loss of Non-diabetic People - PubMed

Low-dose semaglutide has been found to be effective and safe for short-term weight loss in non-diabetic people.

pubmed.ncbi.nlm.nih.gov

Endocr Metab Immune Disord Drug Targets
2024 May 28.

doi: 10.2174/0118715303283400240521120048. Online ahead of print.

Efficacy and Safety of Semaglutide in Weight Loss of Non-diabetic People​

Cai-E Song 1, Yan Wang 2, Xue-Mei Dai 3, Hong-Yan Wu 1
Affiliations expand

• PMID: 38808720
• DOI: 10.2174/0118715303283400240521120048

Abstract​

Objective: The study aimed to investigate the efficacy and safety of semaglutide in weight loss in non-diabetic people.

Methods: In this study, 84 non-diabetic people who used semaglutide to lose weight in the outpatient department of our hospital from January 1, 2022, to June 30, 2022, were enrolled and compared for changes in body weight, waist circumference, Body Mass Index (BMI), fasting blood glucose, blood pressure, pulse, and body composition (body fat ratio, visceral fat area, and skeletal muscle) before treatment and 12 weeks after the treatment to analyze the weight loss efficacy and safety.

Results: After administering semaglutide 0.25 mg, 0.5 mg, 0.75 mg, or 1 mg subcutaneously once a week for 12 weeks, 84 participants in this study obtained an average weight loss of 5.91 ± 3.37 kg, equivalent to 6.15 ± 4.28% of baseline body weight, and there was also a significant reduction in visceral fat area and a slight reduction in blood pressure. The most common adverse reactions included gastrointestinal reactions (nausea, vomiting, and diarrhea), which were mild and subsided within 1-2 days. No severe adverse reaction, such as hypoglycemia and hypotension, was observed.

Conclusion: Low-dose semaglutide has been found to be effective and safe for short-term weight loss in non-diabetic people.

 

[Paramuscle]

I had to come off of it, it was messing with my gallbladder. I have heard of several people that have had similar issues. I was having extreme right upper quadrant pain and ended up in the ER with it. My wife is an FNP and she has had a couple of patients with similar complaints. Apparently it doesn't happen a lot but it does happen. Just FYI



~PM

 

[Wilson6]

I had to come off of it, it was messing with my gallbladder. I have heard of several people that have had similar issues. I was having extreme right upper quadrant pain and ended up in the ER with it. My wife is an FNP and she has had a couple of patients with similar complaints. Apparently it doesn't happen a lot but it does happen. Just FYI



~PM

1:200 have gastroparesis. The sides are more common than docs will tell you, but splitting the dose into two a week goes a long way at mitigating some of the GLP-1 sides, or just start with Retatrutide, much better option. Same or better effects and less GI sides in low doses.