Reta vs Tirzep dosing?

[Lizard King]

Been taking the tirzep since January and honestly haven't lost anything since I stopped taking DNP with it, no real change in hunger at all, just bloated. Last dose was 10mg, MD bumped me up to 12.5mg for next week but new insurance doesn't cover it and I'm not paying for something that isn't working.

I heard the Reta works much better, just don't know if I can just switch and if so, what would be a dose to start with coming from 10 - 12.5mg of the Tirzep?

OR do I go with the SLU-PP?

Thanks you sexy bastards.

 

[FlyingDragon]

You have a Dr. who will prescribe Retatrutide?

 

[Massive G]

Been taking the tirzep since January and honestly haven't lost anything since I stopped taking DNP with it, no real change in hunger at all, just bloated. Last dose was 10mg, MD bumped me up to 12.5mg for next week but new insurance doesn't cover it and I'm not paying for something that isn't working.

I heard the Reta works much better, just don't know if I can just switch and if so, what would be a dose to start with coming from 10 - 12.5mg of the Tirzep?

OR do I go with the SLU-PP?

Thanks you sexy bastards.

How were you dosing the tirzepatide?
Once a week? Retatrutide will definitely melt the fat off of you
If you are taking it weekly vs meat heads like us microdosing I would start at 2 mg. It might not work on lizards though but yeah I wouldn't pay for shit that isn't working.

 

[Bigtex]

Been taking the tirzep since January and honestly haven't lost anything since I stopped taking DNP with it, no real change in hunger at all, just bloated. Last dose was 10mg, MD bumped me up to 12.5mg for next week but new insurance doesn't cover it and I'm not paying for something that isn't working.

I heard the Reta works much better, just don't know if I can just switch and if so, what would be a dose to start with coming from 10 - 12.5mg of the Tirzep?

OR do I go with the SLU-PP?

Thanks you sexy bastards.

@Lizard King, I had a lot of hope for the GLP-1 products at first probably mostly because the hype of their commercials on TV. But after my wife trying them for almost a year, I am thinking they either don't give these amazing results to everyone or they are total bullshit. I am starting to see more and more admit they are getting little if anything from these products.

Dosing
Semaglutide - starts at 0.25 mg weekly and gradually increases to a therapeutic dose of 1.0-2.4 mg weekly.
Tirzepatide - start with a 2.5 mg dose and gradually increase it to one of the maintenance doses of 5 mg, 10 mg, or 15 mg
Retatrutide - start with a 2.5 mg dose and gradually increase it to one of the maintenance doses of 5 mg, 10 mg, or 12mg

My wife tried the Semaglutide (3mg/wk) and it was not worth a shit for her. She has also gone through a kit of Retatrutide and is taking 3mg and it has done very little if anything IMHO. It seems rediculous to me to have to do 2 5mg vials to get a slight decrease in hunger. That is expensive. She was going to try the Tirzepatide but I am thinking this is going to be the same waste of time and money. Those kind of maintenance doses get kind of way too expensive. My wife tells me the extreme weight loss she sees on TV are bullshit but the higher dose of Reta does have a slight calming effect in her appetited. But is it worth the price?

For the money, my wife tried a product called Tesofensine. It was $25 for 100, 500mg pills and it seemed to have more of an effect on the appetite that any of the GLP-1 products have. Myself.....I am not seeing any of these drug work any better for my wife than Metformin. I am starting to not buy into any of the research that has been done because there is so much money being dumped into these products by the companies who produce them.

Pharma prices with GOODRX
Semaglutide - . 4, 0.25mg pens - $1300......that get you through the 1st 4 weeks Maintenance dose of 2.4 mg - $1300
Tirzepatide - 4, 0.25mg pens - $995
Retatrutide is only available black market as it is not through Phase III trials yet. No doubt it will be even more expensive.

By the way, my wife has experimented with different micros, carbs and all protein and even keto and it made no difference in the results.

 

[Lizard King]

You have a Dr. who will prescribe Retatrutide?

Dr. Lizard King lol

 

[Lizard King]

I was taking the Tirzep weekly, started at 2.4mg and up to 10mg now, 12.5mg next week for 4 weeks then done.
Heard the Reta is better from a lot of people so can I just try 4mg a week to start?

Honestly the only thing that ever works for me is DNP, 10000% guaranteed time and time again and predictable weekly weight loss. I have done it for 10years and know exactly what to expect. I stopped early this year due to being on the tirzep and should have just continued my normal routine.

 

[jhotsauce7]

I was taking the Tirzep weekly, started at 2.4mg and up to 10mg now, 12.5mg next week for 4 weeks then done.
Heard the Reta is better from a lot of people so can I just try 4mg a week to start?

Honestly the only thing that ever works for me is DNP, 10000% guaranteed time and time again and predictable weekly weight loss. I have done it for 10years and know exactly what to expect. I stopped early this year due to being on the tirzep and should have just continued my normal routine.

What’s appetite like with that dose of tirz? Cravings /food noise?

following everyone’s GLP threads, as I’m starting sema soon.. my bf% has gotten too high over the past year with lack of training due to injury, and getting old lol…starting to look like a fat powerlifter and I need to do an aggressive recomp now. Planning to do 12-16 weeks with sema then 16 more weeks with Reta and a microdose of sema, as of right now. I’ll create a log when I start for sure.

 

[tommyguns2]

Hey LK, it's bizarre that you're not getting any weight loss from the tirz at that high dose level. Most people lose quite a bit.

If you're going to change over to Reta, I'd start low because if you're not responding at all to the Tirz and the Reta actually works for you, you don't need to start high. I'd go with 0.5mg EOD, hold that for a couple weeks, then double it to 1.0mg EOD.

 

[Bigtex]

Here is what I am finding out

Research indicates that not everyone responds equally to these medications. For instance, a 2024 article noted that about 13.8% of participants in Semaglutide trials did not achieve clinically significant weight loss . This variability can be due to genetics, sex, age, or BMI. Women may lose less weight than men (-11.1% vs. -7.5%, per Nature Medicine 2024), and lower BMI or Asian ethnicity might reduce effectiveness.

BMI
FDA recommends BMI ≥27 kg/m² with conditions, or ≥30 kg/m²; not for those with certain medical histories. My wife for what ever BMI is really worth has a 22.8. So perhaps she is just not fat enough to get results but then these are probably guidelines for insurance coverage.

AGE
Younger people seem to respond better than older people. My wife is 63. These products should work regardless of age.

GENDER
Supposedly women are better responders than men.

DISEASE and METABOLICS
Certain conditions can interfere with weight loss, such as thyroid disorders, polycystic ovary syndrome (PCOS), or metabolic syndrome. Additionally, contraindications like a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) can prevent use, as noted in FDA guidelines . Symptoms like neck mass or trouble swallowing should be monitored, as they could indicate issues requiring treatment adjustment. My wife has none of these.

STRESS and EMOTIONAL ISSUES
Stress or emotional eating can influence eating behaviors, making weight loss harder despite medication. This could be a problem. My wife has a problem with over eating. Obesity runs in her family which she has fought with all her life. Which makes me question how to people get to >27BMI if they could control eating in the 1st place. I would imagine that most who are very over weight have some kind of problem associated with food. To me this is a bullshit excuse.

LIFESTYLE FACTORS
They also answer this by saying you mush take in less calories than youu burn and exercise. Well how do we know this lifestyle change didn't cause the weight loss in the 1st place, especially in those with >27BMI?. To me these GLP-1 products should work on someone with no dietary changes and no addition of exercise. Then we know that while people use GLP-1s you will make changes in weight but for it to continue you have to have a lifestyle change after you stop.

Obviously there are individual difference that may cause some to be non-responders but I am not sure any of the above answers are the reason why. So my Spidey sense start to be activated and forces me to look in other directions. In 2024, more than fifteen million people nationwide took GLP-1-related drugs like Ozempic, generating over $50 billion in sales for pharmaceutical companies. Big Pharma has $2.4 billion tied up in expenses to develop the drug. After Covid, I put very little trust in research. Then I read these silly answers as to why some do not respond.

Semaglutide has been show to reduce appetite by slowing the rate in which the gastric system empties and reducing intestinal motility. This in itself should increase satiety because of the expansion of the walls of the stomach or intestines due to pressure caused by the presence of gases, food, liquids, or other factors. This added pressure appears to quell hunger causing satiety. This happens because a full stomach triggers the release of hormones such as ghrelin, which signals the brain that you are full. Additionally, the stomach's expansion can stimulate the release of other hormone which influence satiety like gastrin, Cholecystokinin (CCK) , Peptide YY (PYY) and GLP-1 (Glucagon-like peptide-1) and Leptin which decrease appetite and increase satiety. So in my mind someone who has issues with controlling Ghrelin may not respond to GLP-s., but is that the true?

Terzepatide works the same way by slowing gastric emptying but also simultaneously stimulates glucagon-like peptide-1 (GLP-1) production naturally which in turns causes satiety.

Retatrutide does all of the above but also works to enhance glucagon production, leading to the breakdown of stored fats and glycogen, thereby increasing basal metabolism.

According to research all of these products should work even if you have Ghrelin or Leptin receptor issues. Supposedly if someone has continual high levels of Ghrelin all of these products should still work because the digestion process slows and all of the other pathways some of these products have still are active. However if you can't control Ghrelin you will still have a high appetite but should still lose weight. GLP-1 products should still work even if the body is not releasing Leptin. So I am lost as to why some people do not respond. But according to everything I have read 13.8 non-responders to any medication is not unusual. So for what ever reason, some of us may not have any results while others may.

 

[NuSciencePeptides]

Reta typically works better for many, @Lizard King hit me up and I will send you some to try.

 

[Wilson6]

There was a WSJ article on micro dosing the GLPs and how some people are super responders and only need small doses for positive outcomes or maint dosing with few if any side effects, just enough to take the edge off cravings as many have found here and make it affordable. Of course clinicians are against the idea as is Big Pharma, they just want to nuke it with high and escalating dosing to maximize wt loss. The compounders argue that the dosing should be tailored to the patients needs. In the end, everyone is different and you have to figure out what works best for you needs and individual responses.

 

[Mike_RN]

@Lizard King, I had a lot of hope for the GLP-1 products at first probably mostly because the hype of their commercials on TV. But after my wife trying them for almost a year, I am thinking they either don't give these amazing results to everyone or they are total bullshit. I am starting to see more and more admit they are getting little if anything from these products.

Dosing
Semaglutide - starts at 0.25 mg weekly and gradually increases to a therapeutic dose of 1.0-2.4 mg weekly.
Tirzepatide - start with a 2.5 mg dose and gradually increase it to one of the maintenance doses of 5 mg, 10 mg, or 15 mg
Retatrutide - start with a 2.5 mg dose and gradually increase it to one of the maintenance doses of 5 mg, 10 mg, or 12mg

My wife tried the Semaglutide (3mg/wk) and it was not worth a shit for her. She has also gone through a kit of Retatrutide and is taking 3mg and it has done very little if anything IMHO. It seems rediculous to me to have to do 2 5mg vials to get a slight decrease in hunger. That is expensive. She was going to try the Tirzepatide but I am thinking this is going to be the same waste of time and money. Those kind of maintenance doses get kind of way too expensive. My wife tells me the extreme weight loss she sees on TV are bullshit but the higher dose of Reta does have a slight calming effect in her appetited. But is it worth the price?

For the money, my wife tried a product called Tesofensine. It was $25 for 100, 500mg pills and it seemed to have more of an effect on the appetite that any of the GLP-1 products have. Myself.....I am not seeing any of these drug work any better for my wife than Metformin. I am starting to not buy into any of the research that has been done because there is so much money being dumped into these products by the companies who produce them.

Pharma prices with GOODRX
Semaglutide - . 4, 0.25mg pens - $1300......that get you through the 1st 4 weeks Maintenance dose of 2.4 mg - $1300
Tirzepatide - 4, 0.25mg pens - $995
Retatrutide is only available black market as it is not through Phase III trials yet. No doubt it will be even more expensive.

By the way, my wife has experimented with different micros, carbs and all protein and even keto and it made no difference in the results.

Did your wife have any rebound depression after stopping the Tesofensine? I’ve never used any MAOIs but have seen pretty impressive results in friends with 0.5mg/day over a few months. Neither one o& them wants to come off though, I’d prefer to cycle it but would worry about tapering off right.