Used Wicked Labz 20mg (2 a day) 2 weeks on / 1 week off for a couple months — several cycles this way. No difference in noticeable fat loss for me. However I did have a noticeable increased cardio output. Developed a few small skin tags — I don’t know that it can be specifically attributable to the carderine though. I cut one off with tiny scissors that was visible on my neck (the largest, which wasn’t very big at all),and the others I’ve just recently began putting some iodine on a couple times a day. They’re slowly shrinking.