peptides for nerve regeneration and neuropathy

[daman1]

Does anyone know of any peptides that actually work for neuropathy and/or nerve regeneration?

 

[jipped genes]

Bro, I too have been searching for this for my wife. I will say that ALA and curcumin has helped but I think we are going to try ARA 290. Gabapentin helps for sure but I think if she can reduce the nerve inflammation she can get even more relief.

“This phase 2b, 28-day, randomized trial of 64 subjects with sarcoid-associated SNFL [small nerve fiber loss] and neuropathic pain assessed the effect of cibinetide on corneal nerve fiber area (CNFA) and regenerating intraepidermal fibers (GAP-43+) as surrogate endpoints for disease modification, pain severity, and functional capacity”

“…Pain improved significantly in all groups, with subjects having moderate-severe pain reporting a clinically meaningful placebo-corrected decrease in pain intensity in the 4 mg group” (Source)

“The ARA 290 group showed significant (p < 0.05) improvement at wk 4 in small fiber neuropathy screening list score compared with placebo.”

Additionally, the ARA 290 group showed a significant change from baseline in the pain and physical functioning dimensions of the SF-36. The mean Brief Pain Inventory and Fatigue Assessment Scale scores improved significantly but equivalently in both patient groups” (Source)

 

[Snachito1]

Bro, I too have been searching for this for my wife. I will say that ALA and curcumin has helped but I think we are going to try ARA 290. Gabapentin helps for sure but I think if she can reduce the nerve inflammation she can get even more relief.

“This phase 2b, 28-day, randomized trial of 64 subjects with sarcoid-associated SNFL [small nerve fiber loss] and neuropathic pain assessed the effect of cibinetide on corneal nerve fiber area (CNFA) and regenerating intraepidermal fibers (GAP-43+) as surrogate endpoints for disease modification, pain severity, and functional capacity”

“…Pain improved significantly in all groups, with subjects having moderate-severe pain reporting a clinically meaningful placebo-corrected decrease in pain intensity in the 4 mg group” (Source)

“The ARA 290 group showed significant (p < 0.05) improvement at wk 4 in small fiber neuropathy screening list score compared with placebo.”

Additionally, the ARA 290 group showed a significant change from baseline in the pain and physical functioning dimensions of the SF-36. The mean Brief Pain Inventory and Fatigue Assessment Scale scores improved significantly but equivalently in both patient groups” (Source)

What dosage do you plan on starting with? This stuff has my ears perked up as my wife suffers from nerve pain!!

 

[fasttwitch]

Bro, I too have been searching for this for my wife. I will say that ALA and curcumin has helped but I think we are going to try ARA 290. Gabapentin helps for sure but I think if she can reduce the nerve inflammation she can get even more relief.

“This phase 2b, 28-day, randomized trial of 64 subjects with sarcoid-associated SNFL [small nerve fiber loss] and neuropathic pain assessed the effect of cibinetide on corneal nerve fiber area (CNFA) and regenerating intraepidermal fibers (GAP-43+) as surrogate endpoints for disease modification, pain severity, and functional capacity”

“…Pain improved significantly in all groups, with subjects having moderate-severe pain reporting a clinically meaningful placebo-corrected decrease in pain intensity in the 4 mg group” (Source)

“The ARA 290 group showed significant (p < 0.05) improvement at wk 4 in small fiber neuropathy screening list score compared with placebo.”

Additionally, the ARA 290 group showed a significant change from baseline in the pain and physical functioning dimensions of the SF-36. The mean Brief Pain Inventory and Fatigue Assessment Scale scores improved significantly but equivalently in both patient groups” (Source)

Let us know how it goes, Jipped. Mu mother in law is ready to try something different. The doctors have her on Gabapentin, but she is not getting enough relief.

 

[jipped genes]

Fellas, I am still just doing research now. i will keep y'all apprised as we progress. Probably start at .5 mg ed for a month and see how that goes. Might break those into morning and evening as the half life is about 3-4 hours.