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Orals Dont Work

M

metsfan4life

VIP Member
Jan 2, 2014
191
48
#1
Ok so this is a thread started by Jin on another forum based on our discussion - he knows Im weird as a mofo when it comes to anabolics and what works. So I'll let him chime in with his experience and how this got started.

But basically this is cross posted from another forum but felt it would also be a good idea to bring it over here for some additional thoughts as there are also some pretty good people with knowledge and medical sense as well.

Pretty much for me - there are a limited amount of things that work for me, plain and simple. Have been trying to determine this for years. I can take as much orals as you want and I will get zero, yes ZERO of anything from it - other than elevated as hell liver levels. 150mg+ Dbol at one time, 150mg+ Adrol, 150mg Winstrol for weeks at a time and not a single pop in joint, etc. Ive also ran clen 200mcg in one sitting with nothing. Now, obviously might think - its junk. No, its from a good source and on several different occasions, hand the exact stuff to a buddy and whatdyaknow - its def not fake. But anyways, this also goes for almost any AAS - also injectable orals have no effect. Ill go into more detail later, just wanted to post up.

Primary purpose - thread got started and many over there know my experience with weird oddities. A fellow board member messaged me some really good information to look into. I had always had a wonder if it were possible to have such a thing but what he has pointed out, I have to tend to agree to at this time as it has some legs and the more I dig into and look at it, it makes a lot of sense. Will post it in the next portion. But again, love to hear some people's input.

@Jin , get in here
 
M

metsfan4life

VIP Member
Jan 2, 2014
191
48
#2
Reason 1: You are a CYP2D6/CYP2C19/CYP3A4 "ultra-rapid metabolizer". Your CYP liver enzymes metabolize the hormones too quickly for your body to have adequate exposure to the hormones. Patients taking CYP-mediated opioids like codeine, hydrocodone, etc are required higher dosages due to the ultra-rapid metabolizing.

Reason 2: You are ingesting things that affect your liver enzymes. Thus you are not getting adequate metabolism, and thus exposure, to the hormones.

Reason 3: You are a poor metabolizer due to having ineffective enzyme variants. The other end of the spectrum.

  • Take 2 empty cups: Cup A and Cup B.
  • The cups=2 different variants of the human body.
  • Poke a large hole on the bottom of Cup A.
  • Poke a tiny hole on the bottom of Cup B.
  • The holes=metabolizing and excreting medicine.
  • Pour water into each cup.
  • Water=a compound (oral AAS, opioids, etc).
What happens? The water (medicine) in Cup A leaves the cup (human body) FASTER than the tiny hole in Cup B.

Ultra-rapid metabolizers are Cup A. Normal metabolizers are Cup B. Ultra-rapid metabolizers will NOT get an adequate body plasma concentration of a medicine-right after you take the medicine it's metabolized and excreted before it can build up in your body!

The same thing happens for those on the opposite end: those with inactive CYP enzymes. Compounds are excreted without being metabolized at all; ergo a person is void of any effect from ingesting the compounds.





https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975340/

https://www.pharmvar.org/gene/CYP2C19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663206/
 
tommyguns2

tommyguns2

Senior Moderators
Staff Member
Dec 25, 2010
4,549
1,794
#3
So you're saying that orals don't work for you in particular, and you're not saying that orals do work generally?

If it's the former, I'll have to defer to your statements, as you appear to have run various orals in a controlled manner to make that determination.
 
M

metsfan4life

VIP Member
Jan 2, 2014
191
48
#4
@tommyguns2 yes that is correct. Whether that be an AAS or a lot of Rx. Pain killers in general are non effective to me. When I say that, I mean in a controlled manner as well as I have never taken drugs recreational (AAS is my sole vice),never touched weed nor cigarettes nor drank a sip of alcohol. I have taken several different oral AAS over the years as I know each person typically has a go to for instance, as many do the best way to find the right one is to try the next one (within reason). They have always been ran at “normal” amounts and have ramped up to determine if tolerance is needed as it is for me with tren (I have no sides from tren whatsoever). Dbol adrol win var have all been ran at high dose with nothing.

@Jin has had a recent similar effect to comment to.

I can take 100+ on Viagra and no headache or anything, but bad thing is it also does not increase or provide the “umpth”. It’s not needed but you know...for the fun occasion.


If any particular questions that you may have that I can answer I will.
 
M

metsfan4life

VIP Member
Jan 2, 2014
191
48
#6

Motivated by nothing more than my pure snoopiness, but with that offer as my excuse, I have 2:

1) so what has/does work for you within our part of the chemistry game, while not dosing so high that the sides become dangerous, i.e. what keeps you in the game? Question applies not only to the goodies we take to reap benefits, but also to the things we take during and after to minimize the sides?

Essentially what has worked: injects of normal Test - E/C/P are fine, Tren A (didnt care much for E) and Mast are pretty much my go to. I have run high doses of all 3 and TRT levels (I am on 100mg/wk of TC from my endocrine - type 1 diabetic). I dont use any orals at all any more b/c like you said, there is no benefit to me whatsoever to them. What is odd tho is that Aromasin keeps my E2 at the correct levels while not on TRT doses. I still use the injects as many others do as it does still provide benefits. I notice a difference on the Tren at a lower level of 300mg/wk in comparison to a higher level of 600+, not massive amounts but yes. I had always wondered like with the clomid - everyone always joked about the end result of it, never had that effect and now wonder if maybe this played a part into the reduction of recovery. after 1st cycle - solely Test, AI, and PCT, never recovered as much, 2nd cycle, same, 3rd, never made it above 250 i believe. Random - I have 0 atrophy due to high test usage, ever. Even on 1st. But additionally, even TNE at 150mg does nothing for me which is what I have always found odd.


2) How are you and the doctors gonna deal with it if the need for surgery ever comes up? I'm assuming anesthesia drugs might create a problem similar to, but riskier than, PED drugs(?) Seems like at a certain increased dose an anesthesia drug would become a euthanasia drug?

Thats actually what Im wondering as well. My liver levels right now are severely elevated. I have never had any liver elevations unless I was on an oral at the time. I have binged on the aids but they have not reduced a single sliver. have a consultation next week for that. I have ran tren in the past with no liver issues. Initially thought it was a compound of usage on inject oral that have tried from a good source but hadnt been n that for weeks before 1st run of liver test and then over a month later (no inject of that at all) and liver same.
 
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