- Dec 17, 2019
I think it really boils down to how one feels at a given dose and goals with body composition and perceived QOL and what level of risk one is willing to accept for those goals along with genetics for side effects long term. If one is taking 300 mg/wk (mostly T and some non-C-17 methylated androgens) and feels good, likes the level of strength and body comp at that dose, labs are good and yearly echo is unchanged then one could probably run that dose for life, for someone else maybe not. As you get older metabolism of T decreases, thus less clearance and higher blood levels. Bhasin showed that with the high dosing studies with younger and older guys. In addition, we become androgen insensitive. 100 mg of week 30 years ago was great, now 200 mg/wk is necessary to even get close to feeling normal and fighting the loss of lean bc of aging. Blood levels are fine, but like insulin, anti-depressants and many other drugs, the same blood level can have widely varying effects on different individuals, androgens are no different even though we treat that way). I think we frame HRT or cycle to make ourselves feel better like HRT isn't a cycle, anything more than 300/wk yes and that wouldn't be long term. While not proven and probably never will be, my gut tells me in otherwise healthy guys that are trying to optimize body comp with resistance exercise and diet, a base dose of 200 - 300 mg/wk with maybe a 12 week cycle of up to 500 mg/wk for 10 - 12 weeks once or twice a year (with lower risk androgens) probably will not take any years off of one's life span and probably provide a QOL that would have been otherwise impossible to achieve. BUT, that would be under medical supervision, not just assuming you'll be OK. I believe less for longer vs blast/cruise is better for overall health and will allow one to attain their goals, while it may take longer, gains are maintained vs blowing up and shrinking over and over and subjecting the body to considerable ROS stress. Just my two cents.300mg per week with ND seems more like a cycle to me but whatever works for you I guess. Some would likely say the same thing about my doses. I like my levels to be in the 800-1,100 range. I think most Drs around here are pretty conservative and don't do WWE and UFC level TRT.