Sep 4, 2010 Tamoxifen Citrate (Nolvadex) This drug is a potent nonsteroidal anti-estrogen. It is intended for use in estrogen dependent tumors, i.e. breast cancer. Steroid users take Nolvadex to prevent the effects of estrogen in the body. This estrogen is most often the result of aromatizing affect of steroids. It can aid in preventing edema, gynecomastia, and female pattern fat distribution, all of which might occur when a man’s estrogen levels are too high. Also these affects can occur when androgen levels are too low, making estrogen the predominant hormone. This can occur when endogenous androgens have been suppressed by the prolonged use of exogenous steroids in combination with cutting of these exogenous sources. Nolvadex works by competitively binding to target estrogen sites like the breast. This drug is not toxic nor have any side effects been seen in athletes who used the drug as an anti-estrogen. This drug is the most popular anti-estrogen among steroid users by far. Although this drug does not turn out to be 100% effective for everyone, it does seem to exhibit some level of effectiveness for all. It works so well for some bodybuilders, they can take untraditional drugs like Dianabol or Anadrol right up to a contest as long as they stack it with Nolvadex. It would seem wise to take this drug in conjunction with any steroid cycle. Most reported a dosage of 10mg to 20mg daily got the job done. Availability of Nolvadex has been fair on the black market. Nolvadex is very comparable to Clomid, behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid. The two molecules are also very similar in structure. It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing. The claim that Nolvadex reduces gains should not be taken too seriously. The fact is that any number of bodybuilders have made excellent gains while using Nolvadex. The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction in IGF-1 (individuals using anabolic steroids were not studied though) from use of Nolvadex. Thus, Dan Duchaine reported that it reduces IGF-1 and therefore reduces gains. However, if this effect exists at all, it must be very minor, due to the excellent gains that many have made, and from the fact that no one has noticed any such thing from Clomid, which has the same activity profile. However, I would not be surprised if one were to tell a steroid user that Clomid reduced his gains, he would immediately become afraid that Clomid reduced his gains (please note that no one I have ever heard of has noticed this.) Not having been so misled, however, he would not conclude this from his results. But if an authority publishes that such an effect occurs, whether it does or not it can become self-fulfilling by biasing the user. The fact that Nolvadex will reduce water retention may result in the user agreeing that gains are less, since weight gain is less, thus reinforcing the bias. Many bodybuilders take 10-20 mg of Nolvadex each day for the last month prior to a bodybuilding contest to help reduce water retension and increase muscle hardness.