Happens every time I try to inject more than 2mls. So I try not to. Back to your original question. I personally would split the dose. We all hate pinning at this point and anyone that says they enjoy it has a serious screw loose! Lol. But I would rather split it. I seem to get more acne and mood swings when I let levels vary too much. Not really mood swings but I will have that good sense of well being the first few days and then I won’t the last few before next inject. I rather stay even keel. Never really noticed oily skin changes. For me that’s just dose dependent.