I have used it off and on as it has great benefits across the body. My problem is "GI" issues if I run anything over 2xday @ 500mg.
Quick article by LEF about new FDA trials:
Metformin the First Anti-Aging Drug - - Life Extension
That’s how I regularly am so I wouldn’t expect any change to the status quoGI issues usually go away in a few weeks, at least it did for me. One side effect to be careful about, sometimes when taking a pee will result in an unwanted bowel movement. There is sometimes no control over the poop coming out.....
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