
Bigtex
VIP Member
- Aug 14, 2012
- 1,468
- 2,272
Great Video - patients taking testosterone + anastrozole did not reduce visceral fat mass when compared to testosterone alone. Testosterone by itself is anti-inflammatory AI's prevent this which can lead to cardiac damage.
What are the benefits of micro-dosing and IM vs sub-q?
Ng Tang Fui M, Prendergast LA, Dupuis P, Raval M, Strauss BJ, Zajac JD, Grossmann M. Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial. BMC Med. 2016 Oct 7;14(1):153. doi: 10.1186/s12916-016-0700-9. PMID: 27716209; PMCID: PMC5054608.
pubmed.ncbi.nlm.nih.gov
bmcmedicine.biomedcentral.com
Conclusions
Among obese men with a low to low-normal testosterone typical for the majority of obese men, testosterone treatment augmented diet-induced loss of total fat and visceral fat mass, and preserved lean mass so that, in contrast to placebo-treated men who lost both lean and fat mass, diet-induced weight loss during testosterone treatment was almost exclusively due to the loss of body fat.
Discussion
The major novel findings of this RCT are that, among obese men with low to low-normal testosterone submitted to a weight loss program, testosterone treatment decreased total fat mass and visceral adipose tissue, and protected against loss of total and appendicular lean mass.
Holland AM, Roberts MD, Mumford PW, Mobley CB, Kephart WC, Conover CF, Beggs LA, Balaez A, Otzel DM, Yarrow JF, Borst SE, Beck DT. Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism. J Appl Physiol (1985). 2016 Sep 1;121(3):792-805. doi: 10.1152/japplphysiol.00238.2016. Epub 2016 Aug 18. PMID: 27539493.
Overall, these findings indicate that the lipolytic and antilipogenic effects of TEST are enhanced by aromatase activity, indicating both androgenic and estrogenic regulation of adiposity in male visceral adipose tissue. Future research evaluating the time-course responses of visceral adipose tissue to TEST administration with and without aromatase inhibition would assist in elucidating the androgen/estrogen-mediated pathways regulating adiposity.
Steiner BM, Berry DC. The Regulation of Adipose Tissue Health by Estrogens. Front Endocrinol (Lausanne). 2022 May 26;13:889923. doi: 10.3389/fendo.2022.889923. PMID: 35721736; PMCID: PMC9204494.
pmc.ncbi.nlm.nih.gov
Sebo ZL, Rodeheffer MS. Testosterone metabolites differentially regulate obesogenesis and fat distribution. Mol Metab. 2021 Feb;44:101141. doi: 10.1016/j.molmet.2020.101141. Epub 2020 Dec 9. PMID: 33307216; PMCID: PMC7772371.
pmc.ncbi.nlm.nih.gov
Juang PS, Peng S, Allehmazedeh K, Shah A, Coviello AD, Herbst KL. Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: a randomized controlled trial. J Sex Med. 2014 Feb;11(2):563-73. doi: 10.1111/jsm.12368. Epub 2013 Nov 6. PMID: 24344872.
Cruz-Topete D, Dominic P, Stokes KY. Uncovering sex-specific mechanisms of action of testosterone and redox balance. Redox Biol. 2020 Apr;31:101490. doi: 10.1016/j.redox.2020.101490. Epub 2020 Mar 5. PMID: 32169396; PMCID: PMC7212492.
pmc.ncbi.nlm.nih.gov
ESTRADIOL Ultra Sensitive (LC/MS) Blood Test
This ultrasensitive estradiol test is recommended for men. The commonly used estradiol test may overestimate estradiol in men. That test uses immunoassay technology that cannot differentiate C-Reactive Protein (involved in inflammation) from estradiol, so it reads the combination of the two as estradiol. This ultrasensitive estradiol test is based on liquid chromatography/mass spectrometry (LC/MS), an assay technology that does not have that limitation
www.discountedlabs.com
What are the benefits of micro-dosing and IM vs sub-q?
Ng Tang Fui M, Prendergast LA, Dupuis P, Raval M, Strauss BJ, Zajac JD, Grossmann M. Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial. BMC Med. 2016 Oct 7;14(1):153. doi: 10.1186/s12916-016-0700-9. PMID: 27716209; PMCID: PMC5054608.

Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial - PubMed
clinicaltrials.gov, identifier NCT01616732 , registration date: June 8, 2012.


Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial - BMC Medicine
Background Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass. Methods We conducted a randomised double-blind...

Conclusions
Among obese men with a low to low-normal testosterone typical for the majority of obese men, testosterone treatment augmented diet-induced loss of total fat and visceral fat mass, and preserved lean mass so that, in contrast to placebo-treated men who lost both lean and fat mass, diet-induced weight loss during testosterone treatment was almost exclusively due to the loss of body fat.
Discussion
The major novel findings of this RCT are that, among obese men with low to low-normal testosterone submitted to a weight loss program, testosterone treatment decreased total fat mass and visceral adipose tissue, and protected against loss of total and appendicular lean mass.
Holland AM, Roberts MD, Mumford PW, Mobley CB, Kephart WC, Conover CF, Beggs LA, Balaez A, Otzel DM, Yarrow JF, Borst SE, Beck DT. Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism. J Appl Physiol (1985). 2016 Sep 1;121(3):792-805. doi: 10.1152/japplphysiol.00238.2016. Epub 2016 Aug 18. PMID: 27539493.
Overall, these findings indicate that the lipolytic and antilipogenic effects of TEST are enhanced by aromatase activity, indicating both androgenic and estrogenic regulation of adiposity in male visceral adipose tissue. Future research evaluating the time-course responses of visceral adipose tissue to TEST administration with and without aromatase inhibition would assist in elucidating the androgen/estrogen-mediated pathways regulating adiposity.
Steiner BM, Berry DC. The Regulation of Adipose Tissue Health by Estrogens. Front Endocrinol (Lausanne). 2022 May 26;13:889923. doi: 10.3389/fendo.2022.889923. PMID: 35721736; PMCID: PMC9204494.
The Regulation of Adipose Tissue Health by Estrogens - PMC
Obesity and its’ associated metabolic diseases such as type 2 diabetes and cardiometabolic disorders are significant health problems confronting many countries. A major driver for developing obesity and metabolic dysfunction is the uncontrolled ...

Sebo ZL, Rodeheffer MS. Testosterone metabolites differentially regulate obesogenesis and fat distribution. Mol Metab. 2021 Feb;44:101141. doi: 10.1016/j.molmet.2020.101141. Epub 2020 Dec 9. PMID: 33307216; PMCID: PMC7772371.
Testosterone metabolites differentially regulate obesogenesis and fat distribution - PMC
Low testosterone in men (hypogonadism) is associated with obesity and type II diabetes. Testosterone replacement therapy has been shown to reverse these effects. However, the mechanisms by which testosterone regulates total fat mass, fat ...

Juang PS, Peng S, Allehmazedeh K, Shah A, Coviello AD, Herbst KL. Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: a randomized controlled trial. J Sex Med. 2014 Feb;11(2):563-73. doi: 10.1111/jsm.12368. Epub 2013 Nov 6. PMID: 24344872.
Cruz-Topete D, Dominic P, Stokes KY. Uncovering sex-specific mechanisms of action of testosterone and redox balance. Redox Biol. 2020 Apr;31:101490. doi: 10.1016/j.redox.2020.101490. Epub 2020 Mar 5. PMID: 32169396; PMCID: PMC7212492.
Uncovering sex-specific mechanisms of action of testosterone and redox balance - PMC
The molecular and pharmacological manipulation of the endogenous redox system is a promising therapy to limit myocardial damage after a heart attack; however, antioxidant therapies have failed to fully establish their cardioprotective effects, ...

ESTRADIOL Ultra Sensitive (LC/MS) Blood Test
This ultrasensitive estradiol test is recommended for men. The commonly used estradiol test may overestimate estradiol in men. That test uses immunoassay technology that cannot differentiate C-Reactive Protein (involved in inflammation) from estradiol, so it reads the combination of the two as estradiol. This ultrasensitive estradiol test is based on liquid chromatography/mass spectrometry (LC/MS), an assay technology that does not have that limitation

ESTRADIOL , Sensitive (LC/MS/MS)
The most accurate and sensitive estradiol blood test for men based on liquid chromatography, mass spectrometry ( LC/MS )

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