HDL isn't what we once thought it was relative to CAD risk. It is commonly cited as a negative when it comes to even just HRT, higher doses of T along with the other inj (non-C-17) drugs will have some suppressive effect on HDL, question is, does it really matter? Certainly if you're in the single digits and LDL/Trigs are sky high, you're in trouble, but if LDL/Trigs are under control, and HDL in the 30's, and short term 20's when on an oral, all other risk factors controlled (BP, HBA1c, family history, diet, etc.) as a stand alone probably has little effect on overall risk. Apo B measures are gaining traction above all other variables relative to CAD risk. Probably something we should all start looking at, even the HRT (200 - 300 mg/wk) esp mixed models including nandrolone and drostanolone should look at.