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Hmg ( Human Menopausal Gonadotropin )

MAYO

MAYO

Bad Mother
Sep 27, 2010
2,105
588
#1
Human Menopausal Gonadotropin, seen it briefly mentioned on a few other boards. It is supposed to support spermatogenesis, but not many details. Seems to be popping up more frequntly in the shops, or maybe I'm just now noticing it. Anyone currently use HMG or have any experience with it? All input appreciated.

MAYO
 
Rein

Rein

MuscleHead
Sep 10, 2010
1,241
128
#3
I had read a report in which an Endocrinologist managed to make a bodybuilder's HPTA fuction normally again after he was severely shut down from Deca for 3 (!) years continuously just by using HMG.
 
bigrobbie

bigrobbie

MuscleHead
Sep 19, 2010
509
143
#4
HMG was developed as a male fertility aid. It's more frequently used bro HCG is an LH peptide, HMG is an FSH peptide. I think it's probably an under appreciated compound. 75iu/wk, to my knowledge, is sufficent to use as part of a PCT. This is what I've read and retained, not sure if I'm accurate bro...I'd like to try it personally.
 
B

bigscott

Member
Oct 22, 2010
48
2
#7
would like to learn more about this !!! would greatly benefits guys coming off imo
 
jdjack

jdjack

MuscleHead
Sep 22, 2010
568
32
#8
You'd use it like HCG 2-3x/wk. It is used in fertility treatment to increase sperm load. Its MUCH more expensive, and comes in either 75mg or 150mg amps. Normal use is 75mg per dose. I don't think most ppl need to use it unless you're doing a very long and suppressive cycle.
 
jdjack

jdjack

MuscleHead
Sep 22, 2010
568
32
#9
Found this. Hope it helps.

HMG is typically used to treat infertility . Basically, long term use of HCG at doses of 1000 i.u. 3 or more times weekly causes suppresion or insensitivity of Luetinizing hormone (LH) and to some degree Follicle stimulating hormone (FSH).

Body builders who dont respond to the classic PCT schemes of low dose HCG and clomid for a few weeks will definitley have a hard time with recovery and may encounter depression, a lacking sexual drive, low testicular weight along with low semen/sperm volume.

HMG is Follicle stimulating hormone (FSH) and luetinizing hormone (LH). This simply stimulates your natural test production and keeps HCG working optimally. Your sex drive and sense of well being come back more rapidly then with other treatmentsr as well as your potential for staying or becoming fertile.

Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are called gonadotropins because stimulate the gonads - in males, the testes, and in females, the ovaries. They are not necessary for life, but are essential for reproduction. These two hormones are secreted from cells in the anterior pituitary called gonadotrophs. Most gonadotrophs secrete only LH or FSH, but some appear to secrete both hormones.

As described for thyroid-simulating hormone, LH and FSH are large glycoproteins composed of alpha and beta subunits. The alpha subunit is identical in all three of these anterior pituitary hormones, while the beta subunit is unique and endows each hormone with the ability to bind its own receptor.

In both sexes, LH stimulates secretion of sex steroids from the gonads. In the testes, LH binds to receptors on Leydig cells, stimulating synthesis and secretion of testosterone. Theca cells in the ovary respond to LH stimulation by secretion of testosterone, which is converted into estrogen by adjacent granulosa cells.

As its name implies, FSH stimulates the maturation of ovarian follicles. Administration of FSH to humans and animals induces "superovulation", or development of more than the usual number of mature follicles and hence, an increased number of mature gametes.

FSH is also critical for sperm production. It supports the function of Sertoli cells, which in turn support many aspects of sperm cell maturation.

Diminished secretion of LH or FSH can result in failure of gonadal function (hypogonadism). This condition is typically manifest in males as failure in production of normal numbers of sperm. In females, cessation of reproductive cycles is commonly observed.

Elevated blood levels of gonadotropins usually reflect lack of steroid negative feedback. Removal of the gonads from either males or females, as is commonly done to animals, leads to persistent elevation in LH and FSH. In humans, excessive secretion of FSH and/or LH most commonly the result of gonadal failure or pituitary tumors. In general, elevated levels of gonadotropins per se have no biological effect.




Heres a quick study:
Ten typical cases of male eunuchoidism (two with anosmia) are reported. After administration of clomifene citrate to five patients, there is no change in blood levels of gonadotrophins in four cases; in the fifth, a small and transitory increase of LH is noted. The intravenous injection of LHRH (100 mug) to five patients induces an increase of serum LH in all cases and serum FSH in three cases. The initial site of the dysfunction is possibly hypothalamic with secondary gonadotrophic pituitary insufficiency. Among six patients anxious for paternity, prolonged treatment (for 36 to 98 weeks),with HCG (250-1 000 I.U. daily) +HMG (65-120 I.U. FSH daily) results in appearance of spermatozoa in the seminal fluid in five cases and a pregnancy was obtained in four cases. Comments are done upon methods of treatment."

"Ten typical cases of male eunuchoidism (two with anosmia) are reported. After administration of clomifene citrate to five patients there was no change in blood levels of gonadotrophins in four cases; in the fifth, a small and transitory increase of LH was noted. The intravenous injection of LHRH (100 mcg) to five patients induced an increase of serum LH in all cases and serum FSH in three cases. The initial site of the dysfunction is possibly hypothalamic with secondary gonadotrophic pituitary insufficiency. Among six patients desiring paternity, prolonged treatment (for 36 to 98 weeks),with HCG(1700-7000 I.U. weekly) + HMG (450-825 I.U. FSG weekly) resulted in the appearance of spermatozoa in the seminal fluid in five cases and a pregnancy was obtained in four cases. Methods of treatment are discussed."

"Although testosterone (T) therapy is sufficient for maturation and maintenance of secondary sex characteristics in hypogonadal men, gonadotropins are required for stimulation of spermatogenesis. Thirteen men with hypogonadotropic hypogonadism received treatment with hCG, followed in 12 by the addition of human menopausal gonadotropin (hMG). All initially had undetectable serum LH and FSH and low T levels and were azoospermic with small testes. During therapy, all achieved normal male levels of T. Twelve of 13 had marked and continuous increase in testicular volume. Three men had sperm in the ejaculate with hCG treatment alone. All but 1 patient developed sperm in their seminal fluid during combined hCG and hMG therapy. Two men achieved three pregnancies, and 2 more had semen that produced hamster oocyte penetration assays in the fertile range during the protocol period. Four of 5 who achieved sperm densities greater than 1 million/ml while receiving combined therapy maintained or increased sperm production while receiving continued hCG therapy after hMG was withdrawn. We examined the response to gonadotropin therapy of men who had received previous T therapy and those who had not. There were no differences in rapidity or degree of response, as assessed by rise in serum T, increase in testis volume, or maximal sperm density achieved. Multiple pituitary deficits and cryptorchidism were negative prognostic factors. In summary, the prognosis for successful stimulation of spermatogenesis in men with hypogonadotropic hypogonadism treated with hCG/hMG is good and not adversely affected by prior androgen treatment. Despite undetectable serum FSH levels, hCG treatment was sufficient to both initiate and maintain spermatogenesis in some patients."

HMG most commenly comes in 75 i.u. ampules. They work Sub-Q as well as I.M.

Whether your shut down hard or just looking for more effective PCT You should always begine with the lowest most effective dose and work from there.

My regimen was simple:

1000 I.U. HCG three times weekly
75 I.U. HMG Three times weekly
50mg clomid daily

Obviously many studies have shown a variation in HCG/HMG doses. I would always advise to start low. A fertility study used a protocol of 2500 I.U. HCG + 300 I.U. HMG two times per week.


Depending on your goals this treatment can last 1-2 years ( for fertility and total recovery). For Bodybuilders who simply want a quick PCT protocol they can run this 4 weeks.

Obviously if your planning on going back on a cycle in a short time this wouldnt be something youd wanna stay on for months.

I believe it still can be an effective short term PCT program and replace your existing protocol if you do plan on running cycles more than two times a year.

I shot the HCG and HMG on the same days with different stick. I used BA for both.

Results are spectacular. Increase in testicle size and weight. Increase semen output. The most important of all.......A sense of well being and normalcy.
 
Bowhunter

Bowhunter

Senior Member
Oct 12, 2010
149
2
#10
Good info on HMG! I have HCG, but HMG sounds like a much better approach.
 
Ms.Wetback

Ms.Wetback

VIP Lady Member
Sep 27, 2010
1,599
118
#11
How about just maintaining testicular size and sperm volume ??
What can guys do about that ???

My husband is on HRT so all of this is useless for him, he is never coming off.
 
jdjack

jdjack

MuscleHead
Sep 22, 2010
568
32
#12
I'd say use HMG, but if he's never coming off, then it'd only be for making kids. Otherwise, really no point. I'd def advise going to a doc and let them watch over it. The investment in the 'pair of eyes' would IMO be well worth it.
 
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