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Hgh, once or twice a day

  • Thread starter MountaineerMuscle84
  • Start Date
Mike_RN

Mike_RN

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Staff Member
Aug 13, 2013
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#13
Preworkout I used to do IM for a faster hit but subq is the manufacturers desired method of delivery.
 
rAJJIN

rAJJIN

TID Board Of Directors
Nov 30, 2011
693
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#16
1/3 of a vial per dose (appx 5iu)
SubQ
Whenever I can remember
 
sityslicker1

sityslicker1

TID Board Of Directors
Oct 6, 2010
717
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#17
I want the lipid intermediates to keep body fat low and also prevent NIDDM (insulin resistance). This is why I run once daily 4iu at bedtime.
The "bioscience" is to shoot it more frequently for more fat loss and this study although limited seems to contradict. However l, I think your method you described here is ideal for longevity and health.
 
Last edited:
mands

mands

VIP Member
Jul 24, 2012
588
175
#18
The "bioscience" is to shoot it more frequently for more fat loss and this study although limited seems to contradict. However l, I think your method you described here is ideal for longevity and health.
Can you point me in the direction what study and where there is a contradiction?

GH can actually take the fatty acids out of the blood stream and move them to skeletal muscle for fuel. The mechanism for fat loss from GH has many pathways but I can tell you smaller dosed shots while semi-fasted will result in much great fat loss than one shot. If you insist on one shot I would suggest doing it in the AM.

The protocol for splitting shots up for example, Morning and Night goes along with being in a semi-fasted state and taking your shots after all foods consumed and before any food is consumed. Also, mimicking natural GH pulses goes in line with greater lipolysis.

Dose dependency of the pharmacokinetics and acute lipolytic actions of growth hormone.
Hansen TK1, Gravholt CH, ØRskov H, Rasmussen MH, Christiansen JS, Jørgensen JO.
Author information

Abstract
The sensitivity to GH is subject to substantial interindividual variations, which has been attributed to differences in age, sex, and body composition. We investigated 18 healthy nonobese men (aged 24-56 yr) on four occasions. The pharmacokinetics and acute lipolytic effects of GH were evaluated using iv bolus injections of either placebo or GH (1, 3, and 6 micro g/kg(-1)). Body composition was determined by computed tomography and bioimpedance measurements, and the lipolytic response was assessed through measurements of circulating lipid intermediates and adipose tissue microdialysis. The metabolic clearance rate was dose dependently reduced with increasing GH doses (57.2 +/- 5.1, 45.2 +/- 3.8, and 39.2 +/- 2.4 ml/min(-1) per meter(-2) following injection of 1, 3, and 6 micro g/kg(-1) GH, respectively, P < 0.001),and half-time was increased (14.2 +/- 0.6, 16.2 +/- 0.4, and 18.0 +/- 0.5 min, respectively, P < 0.0001). The pharmacokinetic variables were not correlated to age or body composition at any GH dose, but GH-binding protein was the major predictor of metabolic clearance rate following the two highest GH doses as indicated by multivariate regression analysis (r(2) = 0.55, P < 0.001 and r(2) = 0.35, P = 0.012, respectively). There was a significant dose-response relationship between injected GH and the subsequent increments in lipid intermediates, but the integrated lipolytic response was not correlated to GH pharmacokinetics, age, or body composition at any GH dose. Taken together, our findings suggest that differences in GH-binding protein concentrations, which possibly reflect GHR expression, determine GH pharmacokinetics rather than age or body composition per se.
PMID: 12364460 DOI: 10.1210/jc.2002-020563

mands
 
DungeonDweller

DungeonDweller

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Mar 21, 2017
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#19
The protocol for splitting shots up for example, Morning and Night goes along with being in a semi-fasted state and taking your shots after all foods consumed and before any food is consumed.
Should you be slightly fasted before taking it? Say you have a snack in the evening, should you wait an hour or so before doing the evening GH?
 
Zomb131

Zomb131

VIP Member
Jan 31, 2011
1,074
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#20
The "bioscience" is to shoot it more frequently for more fat loss and this study although limited seems to contradict. However l, I think your method you described here is ideal for longevity and health.
What study?
 
mands

mands

VIP Member
Jul 24, 2012
588
175
#21
Should you be slightly fasted before taking it? Say you have a snack in the evening, should you wait an hour or so before doing the evening GH?
I would like to see longer than that if all possible. 3-4 hours would be good and if you could get your food intake into a 8 hours window like 10 am - 6 pm then shots at 6am and 10 pm it would ideal for fat loss.

mands
 
mands

mands

VIP Member
Jul 24, 2012
588
175
#22
I would like to see longer than that if all possible. 3-4 hours would be good and if you could get your food intake into a 8 hours window like 10 am - 6 pm then shots at 6am and 10 pm it would ideal for fat loss.

mands
Would like to add if you are really wanting to jump start fat loss adding a few things to work in synergy with the GH is really going to accelerate lipolysis. Adding to a High Test cycle with dose of Clean a day would be awesome.

I noticed I stated AM above in post #18. That should be PM. Ideally would be great to take a shot 8 hours after your last meal. But, that would probably warrant setting an alarm to wake up for your shot :)

mands
 
DungeonDweller

DungeonDweller

VIP Member
Mar 21, 2017
509
245
#23
Thanks @mands, this is good info. For my fatloss/cut I am using GH 2UI once ED along with test prop/tren a/mast p EOD, proviron, clen, DNP ED. I intermittent fast and my eating window is at night (working during the day so I am too busy to notice I'm hungry + I can sleep because I'm fed). I've been doing the GH at night but now I'm seeing that might not be the best timing.
 
MountaineerMuscle84

MountaineerMuscle84

VIP Member
Feb 16, 2019
61
19
#24
Can you point me in the direction what study and where there is a contradiction?

GH can actually take the fatty acids out of the blood stream and move them to skeletal muscle for fuel. The mechanism for fat loss from GH has many pathways but I can tell you smaller dosed shots while semi-fasted will result in much great fat loss than one shot. If you insist on one shot I would suggest doing it in the AM.

The protocol for splitting shots up for example, Morning and Night goes along with being in a semi-fasted state and taking your shots after all foods consumed and before any food is consumed. Also, mimicking natural GH pulses goes in line with greater lipolysis.

Dose dependency of the pharmacokinetics and acute lipolytic actions of growth hormone.
Hansen TK1, Gravholt CH, ØRskov H, Rasmussen MH, Christiansen JS, Jørgensen JO.
Author information

Abstract
The sensitivity to GH is subject to substantial interindividual variations, which has been attributed to differences in age, sex, and body composition. We investigated 18 healthy nonobese men (aged 24-56 yr) on four occasions. The pharmacokinetics and acute lipolytic effects of GH were evaluated using iv bolus injections of either placebo or GH (1, 3, and 6 micro g/kg(-1)). Body composition was determined by computed tomography and bioimpedance measurements, and the lipolytic response was assessed through measurements of circulating lipid intermediates and adipose tissue microdialysis. The metabolic clearance rate was dose dependently reduced with increasing GH doses (57.2 +/- 5.1, 45.2 +/- 3.8, and 39.2 +/- 2.4 ml/min(-1) per meter(-2) following injection of 1, 3, and 6 micro g/kg(-1) GH, respectively, P < 0.001),and half-time was increased (14.2 +/- 0.6, 16.2 +/- 0.4, and 18.0 +/- 0.5 min, respectively, P < 0.0001). The pharmacokinetic variables were not correlated to age or body composition at any GH dose, but GH-binding protein was the major predictor of metabolic clearance rate following the two highest GH doses as indicated by multivariate regression analysis (r(2) = 0.55, P < 0.001 and r(2) = 0.35, P = 0.012, respectively). There was a significant dose-response relationship between injected GH and the subsequent increments in lipid intermediates, but the integrated lipolytic response was not correlated to GH pharmacokinetics, age, or body composition at any GH dose. Taken together, our findings suggest that differences in GH-binding protein concentrations, which possibly reflect GHR expression, determine GH pharmacokinetics rather than age or body composition per se.
PMID: 12364460 DOI: 10.1210/jc.2002-020563

mands
So I am I reading this correctly that the study was done with the subject administering the GH, IV?
 
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