The "bioscience" is to shoot it more frequently for more fat loss and this study although limited seems to contradict. However l, I think your method you described here is ideal for longevity and health.I want the lipid intermediates to keep body fat low and also prevent NIDDM (insulin resistance). This is why I run once daily 4iu at bedtime.
Can you point me in the direction what study and where there is a contradiction?The "bioscience" is to shoot it more frequently for more fat loss and this study although limited seems to contradict. However l, I think your method you described here is ideal for longevity and health.
Should you be slightly fasted before taking it? Say you have a snack in the evening, should you wait an hour or so before doing the evening GH?The protocol for splitting shots up for example, Morning and Night goes along with being in a semi-fasted state and taking your shots after all foods consumed and before any food is consumed.
I would like to see longer than that if all possible. 3-4 hours would be good and if you could get your food intake into a 8 hours window like 10 am - 6 pm then shots at 6am and 10 pm it would ideal for fat loss.Should you be slightly fasted before taking it? Say you have a snack in the evening, should you wait an hour or so before doing the evening GH?
Would like to add if you are really wanting to jump start fat loss adding a few things to work in synergy with the GH is really going to accelerate lipolysis. Adding to a High Test cycle with dose of Clean a day would be awesome.I would like to see longer than that if all possible. 3-4 hours would be good and if you could get your food intake into a 8 hours window like 10 am - 6 pm then shots at 6am and 10 pm it would ideal for fat loss.
mands
Can you point me in the direction what study and where there is a contradiction?
GH can actually take the fatty acids out of the blood stream and move them to skeletal muscle for fuel. The mechanism for fat loss from GH has many pathways but I can tell you smaller dosed shots while semi-fasted will result in much great fat loss than one shot. If you insist on one shot I would suggest doing it in the AM.
The protocol for splitting shots up for example, Morning and Night goes along with being in a semi-fasted state and taking your shots after all foods consumed and before any food is consumed. Also, mimicking natural GH pulses goes in line with greater lipolysis.
Dose dependency of the pharmacokinetics and acute lipolytic actions of growth hormone.
Hansen TK1, Gravholt CH, ØRskov H, Rasmussen MH, Christiansen JS, Jørgensen JO.
Author information
Abstract
The sensitivity to GH is subject to substantial interindividual variations, which has been attributed to differences in age, sex, and body composition. We investigated 18 healthy nonobese men (aged 24-56 yr) on four occasions. The pharmacokinetics and acute lipolytic effects of GH were evaluated using iv bolus injections of either placebo or GH (1, 3, and 6 micro g/kg(-1)). Body composition was determined by computed tomography and bioimpedance measurements, and the lipolytic response was assessed through measurements of circulating lipid intermediates and adipose tissue microdialysis. The metabolic clearance rate was dose dependently reduced with increasing GH doses (57.2 +/- 5.1, 45.2 +/- 3.8, and 39.2 +/- 2.4 ml/min(-1) per meter(-2) following injection of 1, 3, and 6 micro g/kg(-1) GH, respectively, P < 0.001), and half-time was increased (14.2 +/- 0.6, 16.2 +/- 0.4, and 18.0 +/- 0.5 min, respectively, P < 0.0001). The pharmacokinetic variables were not correlated to age or body composition at any GH dose, but GH-binding protein was the major predictor of metabolic clearance rate following the two highest GH doses as indicated by multivariate regression analysis (r(2) = 0.55, P < 0.001 and r(2) = 0.35, P = 0.012, respectively). There was a significant dose-response relationship between injected GH and the subsequent increments in lipid intermediates, but the integrated lipolytic response was not correlated to GH pharmacokinetics, age, or body composition at any GH dose. Taken together, our findings suggest that differences in GH-binding protein concentrations, which possibly reflect GHR expression, determine GH pharmacokinetics rather than age or body composition per se.
PMID: 12364460 DOI: 10.1210/jc.2002-020563
mands
There are currently 0 members watching this topic