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Hgh, once or twice a day

  • Thread starter MountaineerMuscle84
  • Start Date
MountaineerMuscle84

MountaineerMuscle84

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Feb 16, 2019
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I’ve been looking into possibly change my HGH dose to 2ius twice a day instead of 4ius in the morning, I found this study from the early 90s. Thought I’d throw it up. Good Read.

OBJECTIVE: The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficient patients. An improved growth response is obtained in GH deficient children when a fixed weekly GH dose is administered by daily subcutaneous injections instead of twice or thrice-weekly intramuscular injections. A more pulsatile pattern and serum GH levels above zero might be achieved by further increasing the injection frequency. Increased daytime GH levels might, however, adversely affect the circadian patterns of metabolic indices, which have been demonstrated to be more successfully reproduced by evening compared with morning GH administration.
DESIGN AND MEASUREMENTS: In a cross-over study, 8 GH deficient patients (age 16-43 years) were treated with 3 IU/m2/24 h of human GH. The dose was injected in the evening for 4 weeks and for another 4 weeks two-thirds was injected in the evening and one-third in the morning. At the end of each period the patients were admitted to the hospital for 37 hours. Steady-state profiles of GH, IGF-I, IGF binding proteins 1 and 3, insulin, glucose, lipid intermediates and metabolites were obtained following administration of 3 IU/m2 of GH (at 1900 h (one injection) and at 1900 and 0800 h (two injections)).
RESULTS: Similar mean integrated levels of serum GH (mU/l) were obtained (7.46 +/- 0.84 (one injection) vs 6.46 +/- 0.62 (two injections) (P = 0.15)). Mean levels +/- SEM of serum IGF-I (micrograms/l) were significantly increased (P < 0.01) following two daily GH injections (330.3 +/- 48.1 (one injection) vs 399.1 +/- 53.0 (two injections)). Serum IGFBP-3 levels were not significantly different on the two occasions, while levels of the GH independent IGFBP-1 (micrograms/l) were slightly but significantly lower following twice-daily GH injections (1.61 +/- 0.42 vs 1.13 +/- 0.56, respectively (P < 0.04)). The pattern of IGFBP-1 was opposite to that of insulin. Similar levels of insulin and glucose were obtained with both GH regimens, while levels of non-esterified fatty acids were significantly higher following once-daily GH injection (P < 0.001).
CONCLUSIONS: Twice-daily GH injections, apart from producing a more physiological serum GH profile, were superior to one injection in increasing serum IGF-I and decreasing IGFBP-1 levels. Both of these changes tend to amplify the effects of the administered GH. Twice-daily injections, however, resulted in lower night-time levels of lipid intermediates
 
CFM

CFM

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Mar 18, 2012
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I split my dose 12hrs apart to minimize carpel tunnel symptoms.
 
Littleguy

Littleguy

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Sep 30, 2011
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I want the lipid intermediates to keep body fat low and also prevent NIDDM (insulin resistance). This is why I run once daily 4iu at bedtime.

I concur with this:)
 
Rider

Rider

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Aug 27, 2010
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I want the lipid intermediates to keep body fat low and also prevent NIDDM (insulin resistance). This is why I run once daily 4iu at bedtime.

Agreed, I run it like this as well!
 
S

schultz1

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Jan 3, 2011
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I've done it in the morning all one dose, I've split doses and I've sworn gh off... only to have jumped back on last night. I'll he doing 2iu before bed, no more no less. Thanks for posting the study mm84
 
Zomb131

Zomb131

MuscleHead
Jan 31, 2011
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2.5iu AM and 2.5iu PM on training days. I want to maximize IGF secretion, and prevent adipocytes ability to uptake lipids.
 
Last edited:
tommyguns2

tommyguns2

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Dec 25, 2010
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I hope Mands chimes in here, he always has good analysis on this topc.
 
mands

mands

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Jul 24, 2012
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It depends on your goal. But, if you are more focused on lipolysis you would want to spread your gh shots out to at least two. Three would be better IMO. You also want to have at least a 2 hour break from food after your shot. 3 hours would be better.

At the 4 iu dose you are taking and others are taking pre-bed or in the morning will cause minimal or no insulin resistance at that dose. Now, once you start increasing that dose, then you could have issues with insulin resistance. That's why many will introduce insulin around the 8-10 iu mark.

mands
 
ValeTudo8080

ValeTudo8080

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Aug 31, 2011
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How is everyone shooting?......IM or SUBQ
 
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