Get Some
MuscleHead
- Sep 9, 2010
- 3,442
- 651
Just noticed this but wanted to give a quick explanation on Nolva:
Nolvadex is a SERM (Selective Estrogen Receptor Modulator) and NOT and AI (Aromatase Inhibitor). SERMs are more effective in PCT because they help to raise your natural test levels. However, they do not remove any excess estrogen that you may have built up. An AI like letro is a suicide inhibitor that should be used when one already has developed gyno. Arimidex and Aromasin are more for preventative use throughout cycle but can also be used to get rid of gyno. Here is really all you need to know:
Nolva is more of a "blocker"... it does not contend with aromatization other than to occupy cell sites and ligands that would otherwise be occupied by estrogen that is converted via DHT or 5-Alpha Reduced. In other words, once a site is occupied by a newly formed aromatized agent, Nolva will pass up that site to occupy an empty one. Letrozole, on the other hand, will find that agent and remove it from the docking site, freeing the location. In other words it "inhibits suicide" of the estrogen, as previously discussed.
I hope that makes sense and I know most people already know this and that is why I put it in the first cycle thread
I would recommend an AI over Nolva throughout cycle but if you insist on Nolva you must start just prior to the beginning of your cycle to be safe and I would also recommend having an AI on hand in case of estro related side effects that become unmanageable.
Nolvadex is a SERM (Selective Estrogen Receptor Modulator) and NOT and AI (Aromatase Inhibitor). SERMs are more effective in PCT because they help to raise your natural test levels. However, they do not remove any excess estrogen that you may have built up. An AI like letro is a suicide inhibitor that should be used when one already has developed gyno. Arimidex and Aromasin are more for preventative use throughout cycle but can also be used to get rid of gyno. Here is really all you need to know:
Nolva is more of a "blocker"... it does not contend with aromatization other than to occupy cell sites and ligands that would otherwise be occupied by estrogen that is converted via DHT or 5-Alpha Reduced. In other words, once a site is occupied by a newly formed aromatized agent, Nolva will pass up that site to occupy an empty one. Letrozole, on the other hand, will find that agent and remove it from the docking site, freeing the location. In other words it "inhibits suicide" of the estrogen, as previously discussed.
I hope that makes sense and I know most people already know this and that is why I put it in the first cycle thread
I would recommend an AI over Nolva throughout cycle but if you insist on Nolva you must start just prior to the beginning of your cycle to be safe and I would also recommend having an AI on hand in case of estro related side effects that become unmanageable.
