So far, all the are talking about when they say HRT is the benefits of combined estrogen and progestin. Aside from all the benefits of testosterone optimization in women, they have yet to support the importance HRT is to cognitive function and Alzheimer's disease in women. This is still being widely ignored in medicine.
For women — especially postmenopausal or post-oophorectomy — restoring testosterone to physiologic levels (not supra-physiologic) does the following
* Support cognitive resilience
* Reduce dementia risk factors
*Enhance overall mental performance and quality of life
Hogervorst, E., et al. “Low free testosterone is an independent risk factor for Alzheimer’s disease in older women.” Neurobiology of Aging 31 (2010): 157–162.
Davis, S. R., Wahlin-Jakobsen, S. “Testosterone in women—the clinical significance.” Lancet Diabetes & Endocrinology 3 (2015): 980–992.
It would be nice if they included testosterone optimization in women and quit ignoring this. In women, optimal cognition typically requires a balance — not excess testosterone, and not estrogen dominance or deficiency. I think this is a big mistake pushing estrogen and progestin and not looking at testosterone. Having optimized estrogen and progesterone but low testosterone can definitely be a problem for women, especially for long-term metabolic, cognitive, sexual, and emotional health.
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