estrogen 142 on trt

[Wilson6]

Again, you might have that retested using the ultrasensitive estradiol test or Estradiol, Sensitive (LC/MS-MS), It might not be a huge issue unless you are experiencing some unwanted side effects:

• Water Retention & Bloating
• Gynecomastia
• Mood Swings or Irritability
• Erectile Dysfunction or Low Libido
• Fat Gain (especially in hips and thighs)
• Brain Fog or Poor Memory
• Fatigue or Lethargy

I had a 96 maybe 6 months ago, who knows why, but I got it down to 41 in 3 months. I had no unwanted side effects. I just prefer it to be closer to the norm. I added 100mg of masteron enanthate, going 50mg Tues/Thurs and 0.25mg of anastrozole once a week. These readings can change as we age, so it is important that you do blood work at least once every 6 months to keep everything dialed in.

Mine runs about a 1:10 E2:T (pg:ng), thus when T is about 1000, E2 is close to 100, but when I tried either anastrozole (crashed E2 and joints hurt) or Primo E (50 mg/wk) that cut it in half, I couldn't tell a difference either way. ED/libido is age and stress. Hard to mitigate either right now.

 

[BigSwolePump]

Again, you might have that retested using the ultrasensitive estradiol test or Estradiol, Sensitive (LC/MS-MS), It might not be a huge issue unless you are experiencing some unwanted side effects:

• Water Retention & Bloating
• Gynecomastia
• Mood Swings or Irritability
• Erectile Dysfunction or Low Libido
• Fat Gain (especially in hips and thighs)
• Brain Fog or Poor Memory
• Fatigue or Lethargy

I had a 96 maybe 6 months ago, who knows why, but I got it down to 41 in 3 months. I had no unwanted side effects. I just prefer it to be closer to the norm. I added 100mg of masteron enanthate, going 50mg Tues/Thurs and 0.25mg of anastrozole once a week. These readings can change as we age, so it is important that you do blood work at least once every 6 months to keep everything dialed in.

Mood Swings and bad memory for sure, brain fog, fatigue. I piss all day but that is likely old age aka prostate issues so I don't feel like I have water retention but i do have bloating in the stomach area. I find myself a bit emotional lately but I also attributed that to old age(50)

Libido is down a bit but I attribute that to lowering test down to 100mg/wk in an attempt to lower hematocrit levels(54.1 last bw) Still have wood although more like a fig tree than an oak, if you know what I mean.

Also, no sore nips or anything like that.

 

[BigSwolePump]

Are your nips sore?

no sore nips.

 

[Bigtex]

Mood Swings and bad memory for sure, brain fog, fatigue. I piss all day but that is likely old age aka prostate issues so I don't feel like I have water retention but i do have bloating in the stomach area. I find myself a bit emotional lately but I also attributed that to old age(50)

Libido is down a bit but I attribute that to lowering test down to 100mg/wk in an attempt to lower hematocrit levels(54.1 last bw) Still have wood although more like a fig tree than an oak, if you know what I mean.

Also, no sore nips or anything like that.

Then the E2 reading you have is causing you unwanted side effects. See your doctor and ask if he can put you on Anostrozole. Start off with a very low dose and make changes only if it is not working. Your HCT is OK, 55is generally the accepted cut off. I am not a doctor, but I would suggest you take 0.25 mg Anastrozole per week TOTAL on the same days as injection, then reassess after 3–4 weeks, recheck using the sensitive estradiol (LC/MS). If E2 is 30–50 pg/mL keep the dose where it is. if it is higher (>60 pg/mL) I would not go more than 0.5 mg/week, split (0.25 x 2). If the E2 IS<30, stop taking it. Once E2 crashes, recovery can take weeks, even after stopping.

Another thing, if you are taking the whole 100mg of test in 1 injection, I would change that. This usually results in large peaks and deep troughs, which usually cause high aromatization in tissue and possible SHBG dynamics. Instead, split testosterone to 50 mg twice weekly or ~30 mg EOD. This lowers the peaks and troughs and keeps
the testosterone levels in the blood much more stable. That alone can lower any unwanted side effects.

Again, it is important that you recheck labs in 3–4 weeks and then make any adjustments. Once you get the E2 down, you may not need to continue with the AI, as the increased injections will solve the whole problem for you in the future.

 

[JonJon]

Something doesn’t add up here. 142 pg ml e2 on 100mg test a week. Taken tren lately? I’ve heard it can skew e2 readings on the general e2 test.

If you were just taking one shot per week and you were way overweight i could maybe see it, but something isn’t right

 

[JonJon]

Mood Swings and bad memory for sure, brain fog, fatigue. I piss all day but that is likely old age aka prostate issues so I don't feel like I have water retention but i do have bloating in the stomach area. I find myself a bit emotional lately but I also attributed that to old age(50)

Libido is down a bit but I attribute that to lowering test down to 100mg/wk in an attempt to lower hematocrit levels(54.1 last bw) Still have wood although more like a fig tree than an oak, if you know what I mean.

Also, no sore nips or anything like that.

When my E is high it affects my prostate and I pee more

 

[The other Snake]

Keep us posted BSP. The boys got ya covered.

 

[genetic freak]

I am typically a 1:12 when I am around 1000. It seems the lower the test the more skewed the ratio gets towards estrogen and the higher the test the more it skews towards testosterone. I might be 1:8 or 1:9 at 700 and 1:15 when I am 1800 and higher. It doesn't matter if I am stage lean or 15% in full blown growth phase.

I have seen quite a few guys with 1:6 in the 1000-1800 range lately. Food quality, stress load, higher levels of visceral fat, digestive issues, etc... Even had a couple who were 1:5 at 1000 and we couldn't put a dent in it with pharmaceutical aromasin. Had to get the doctor to switch them to anastrozole to get them down to a 1:10.

 

[Wilson6]

I am typically a 1:12 when I am around 1000. It seems the lower the test the more skewed the ratio gets towards estrogen and the higher the test the more it skews towards testosterone. I might be 1:8 or 1:9 at 700 and 1:15 when I am 1800 and higher. It doesn't matter if I am stage lean or 15% in full blown growth phase.

I have seen quite a few guys with 1:6 in the 1000-1800 range lately. Food quality, stress load, higher levels of visceral fat, digestive issues, etc... Even had a couple who were 1:5 at 1000 and we couldn't put a dent in it with pharmaceutical aromasin. Had to get the doctor to switch them to anastrozole to get them down to a 1:10.

"It seems the lower the test the more skewed the ratio gets towards estrogen and the higher the test the more it skews towards testosterone." Makes sense. Aromatase is saturable, so at some point further increases in T don't produce the same elevation in E2.

 

[GreatGunz]

Highest I’ve seen mine is 70 and doc wanted to change all kinds of shit.
I told him no I’m fine I had no side effects.
But we’re all different that number maybe bad for some one else

 

[Bigtex]

Something doesn’t add up here. 142 pg ml e2 on 100mg test a week. Taken tren lately? I’ve heard it can skew e2 readings on the general e2 test.

If you were just taking one shot per week and you were way overweight i could maybe see it, but something isn’t right

Yea, that is kind of low for the dose. But I know my old doctor started my prescription TRT at 150mg/wk and my serum T shot up to 2103. My E2 was 39. Now for whatever reason at 80mg/wk my E2 shot up to 49 after it had been in the high 39's for a while. Who knows what happened. Perhaps it was a bad test, even. Same with this 142, perhaps it was a bad test. I try now not to get too excited when I get bad numbers on an analysis. They usually straighten out by the next test, 3 months later.

We do know that aromatase (the enzyme converting testosterone to estradiol) is not static. It can suddenly spike and settle back down with no changes in dose or no addition of an AI. Things like hepatic clearance vary over time, which affects E2. Small changes in SHBG can make labs look “suddenly worse” even though tissue exposure isn’t dramatically different. Assay variability is a huge possibility. My old doctor told me he has a patient that got lab work done twice in one day. One showed his HCT high, the 2nd showed it much lower. It's always best with TRT to take things slowly and cautiously. Never have knee-jerk reactions. 142 is kind of high IMHO, but I would certainly have it tested again before I started making any changes.

 

[BigSwolePump]

When my E is high it affects my prostate and I pee more

Damn, I wonder if that has something to do with all this pissing? I just saw that on a google search too.

Another high Estrogen side effect