I tried to upload a very recent animal study using Boldenone, file is too big. Ref Frontiers | Boldenone Undecylenate-Mediated Hepatorenal Impairment by Oxidative Damage and Dysregulation of Heat Shock Protein 90 and Androgen Receptors Expressions: Vitamin C Preventive Role | Pharmacology (frontiersin.org) for the full paper. The animals were given 5 mg/kg/wk, divide that by about 6 to get the equiv human dose, we're talking 1 mg/kg, that's not much. Victor Black has been very outspoken about the risks of EQ and we don't have any clinical human studies on it. We have a mountain of human studies over decades on ND with dosing up to 600 mg/wk without any serious side effects. To each his/her own but if one can manage with T vs EQ, esp longer term, probably best to stick with T. EQ generates considerable ROS, no organ system will do well with that, the brain included.
There is a growing body of lit that suggests that the 19-nors are the most neurotoxic (all AAS even T at some point will become neurotoxic), Tren falls in that box for sure. We don't have years of clinical data on Tren like we do ND that has been used clinically for decades. Estrogen and DHT appear to be neuroprotective, one reason T is the best all around base drug. Warhead nailed it, Test, Primo, Mast and Var if the plan is long-term enhancement would likely present the lowest risk, esp if the base (cruise) was mostly T with perhaps some Mast and maybe a little ND (50 - 100 mg/wk) if you're one of those guys that really does get some joint relief with it. There was a study done in 1973 on Mast P for gyno, 50 mg/wk, it shrunk the gyno. There was no effect on LFTs or other blood chems. IMO, just my thinking, a good base high end HRT would be 100 - 150 TC, 50 mg MP and 30 - 50 mg ND (total) per week done with EOD dosing (not to exceed 250 mg total a week). If E2 becomes a problem add a little more MAST and cut back the T a little to find that balance without an AI. Minimize the C-17's and stick to VAR if you use them. Obviously, get blood chems 2 - 3 times a year and an echo baseline and maybe every other year, liver US if you use the C-17's.
Many of the oxandrolone studies in children and burn victims were based on mg/kg body mass dosing. Never seen that approach to HRT in the lit (guys and FTM trans), almost always the end point criteria is to get total T within the normal adult male range 400 - 1100 or so. I think we all know having a T of 400 vs 1100 does make a difference over the long haul. I've seen comments on this board where guys are taking as little as 25 mg TC EOD and have blood conc of T in the 1100 range, that's about 87.5 mg/wk avg, there are women at the gym on that dose (script) and only avg about 450 ng/dl T conc. Other guys are taking 175 a week and are in the 800's. So much variability from person to person relative to rate of appearance of the drug to rate of disappearance of the drug. It's not as simple as give X dose and see X conc in the blood. What I mentioned above is just my thoughts, not a recommendation by any means. The best approach is to see what works best for you and keeping in mind you don't want your total T blood levels much over 1000 if that is the long term base plan, including MAST or ND that won't be measured in the LC/MS-MS T assay. You'd have to assume that if 100 mg of T = X blood conc after X days, then that same X dose of MAST or ND will give the same total blood conc if it were T, and that's a stretch. In the end, come up with a minimal risk plan and implement, give it about 3 months and assess. Fine tune if necessary. Check general chem labs (liver, renal and lipids) and total T (LC/MS assay).
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