dostinex (cabergoline) dose

Discussion in 'PCT - Post Cycle Therapy and Anti-E's' started by wallygator, Nov 3, 2015.

  1. mands

    mands VIP Member

    Jul 24, 2012
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    Well I know for a fact Caber reduces GH and IGF-1 levels. Might not be noticeable but I'm sure not gonna take a drug that does that.

    mands
     
  2. IronCore

    IronCore Bigger Than MAYO - VIP

    Sep 9, 2010
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    tren and test... If find it odd I am one in a million... yet several guys for years get progesterone activity on tren... it was as legit as tren gets these days I would assume. Typically 98% purity in Raw form....So are you saying the only 19nor that can cause progesterone issues would be nandrolone? I haven't run any form of nandrolone in a few years... So I can rule that out rather quickly... All said and done Mands.. I am not here to debate you or PoB... I am just stating my experience.
     
  3. mands

    mands VIP Member

    Jul 24, 2012
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    Never met anyone that has had "prolactin" activity with tren. No need to debate big guy! I just was asking because I've yet to see a Tren powder source that has the type of purity(even oxidation of the product can cause issue).

    What would be a great test IC if you made up a small batch of tren(finaplix pellets) and got bloods again since you seem to be susceptible.

    mands
     
    Last edited: Nov 23, 2015
  4. EastCoast1

    EastCoast1 VIP Member

    Jul 20, 2015
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    He was initially talking Prolactin, you are talking Progesterone. They are not the same. Also do you have any literature on trens binding affinity and activation of the PR? I have seen Bill Roberts say this but never saw what it was based on. I have also seen Seth Roberts talk about Tren being a progesterone agonist.

    I do agree though that most just assume they need to take something to control Prolactin with no actual proof of increased Prolactin. I am with POB that in most cases controled e2 = Controled prolacting.
     
    Last edited: Nov 20, 2015
  5. mands

    mands VIP Member

    Jul 24, 2012
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    Yes sir I know they are different I just wrote progesterone instead of prolacit in my second post you quoted. Sorry for the confusing. I was talking about both or ment to as they are usually discussed with one another. Sorry about that.

    I was getting at in my second post you quoted that there could of been a rise in estrodial and in-turn caused his prolactin to increase. But, IC said his E2 was in check I believe.

    mands
     
    Last edited: Nov 23, 2015
  6. mands

    mands VIP Member

    Jul 24, 2012
    539
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    I will do some digging for you and see if I can find a few studies.

    Here is one I found on initial search. I will look for more.


    [h=4]Send to:[/h]




    APMIS. 2000 Dec;108(12):838-46.
    [h=1]Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor.[/h]Bauer ER1, Daxenberger A, Petri T, Sauerwein H, Meyer HH.
    [h=3]Author information[/h]

    [h=3]Abstract[/h]For the steroidal growth promoters trenbolone acetate (TBA) and melengestrol acetate (MGA) neither the complete spectrum of biological activities nor the potential endocrine disrupting activity of their excreted metabolites in the environment is fully understood. The potency of these substances in [3H]dihydrotestosterone ([3H]-DHT) displacement from the recombinant human androgen receptor (rhAR) and from human sex-hormone binding globulin (hSHBG) was evaluated. In addition, the potency for [3H]-ORG2058 displacement from the bovine uterine progestin receptor (bPR) was tested. For comparison, different anabolics and synthetic hormones were also tested for their binding affinities. For 17beta-trenbolone (17beta-TbOH), the active compound after TBA administration, an affinity the rhAR similar to dihydrotestosterone (DHT) and a slightly higher affinity to the bPR than progesterone were demonstrated. The affinity of the two major metabolites, 17alpha-trenbolone and trendione, was reduced to less than 5% of the 17beta-TbOH-value. The affinity of these three compounds and of MGA to the hSHBG was much lower compared with DHT. MGA showed a 5.3-fold higher affinity than progesterone to the bPR but only a weak affinity to the rhAR. The major MGA metabolites have an affinity to the bPR between 85% and 28% of the affinity of progesterone. In consequence, MGA and TBA metabolites may be hormonally active substances, which will be present in edible tissues and in manure. We conclude that detailed investigations on biodegradation, distribution and bio-efficacy of these substances are necessary.


    PMID: 11252818 [PubMed - indexed for MEDLINE]




    mands
     
    Last edited: Nov 23, 2015
  7. Jimmyinkedup

    Jimmyinkedup Senior Member

    Aug 22, 2012
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    Prolactin can rise on cycle even in the absence of a 19 nor and even when e2 is properly managed. In my experience managing e2 does lower the potential for this effect but it can and does still occur for some. There is a study I have seen posted that suggests that being shut down effects the normal role of repression of prolactin by the androgen receptor in the pituitary.
     
  8. IronCore

    IronCore Bigger Than MAYO - VIP

    Sep 9, 2010
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    here's a question about prolactin and 19nors... Why does it cause ED at times????
     

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