Nov 5, 2015 When it comes to prami tolerance is def a very real issue for some. For those that do tolerate it I think its an excellent choice for the effects I mentioned above as well as ease of availability and stability in liquid form. The effects of all dopamine agonists on the neurological rewards system is a very real concern. The point with a DA IMO , is that it only be used if needed, and only for as long as it is needed. If used in that manner I do not think there would be any adverse , residual long term effects on the neurological rewards system. That would come into play when it would be used on an ongoing basis, almost recreationally for its sexual benefits. That is a no no IMO. Also dosage plays into the equation as well. Even with Prami I think it is often dosed too high. I never need to go over .5mg/day where most of the time I see a dose of 1mg/day recommended. I have not ever found it necessary to take that much. If e2 is managed first and foremost IME the need for a DA drops dramatically.