Dose coq10 have a feedback loop?

[Goldenpuncher]

So, yeah,it's supposed to be something you take after 40, and I'm aware that it won't take me down a huge notch to get a big bottle and stop taking it when it runs out, but will it affect my natural production? Is their a single study on this?

 

[Bigtex]

@Goldenpuncher the body synthesizes CoQ10 through the mevalonate pathway, the same pathway used to produce cholesterol. This process occurs primarily in the liver and is influenced by diet, age, and certain medications (e.g., statins, which inhibit this pathway and reduce CoQ10 levels). Unlike some hormones (e.g., testosterone), where external supplementation can suppress natural production via feedback loops, CoQ10 doesn’t appear to have a strong feedback mechanism that halts its synthesis. Studies suggest that supplemental CoQ10 increases plasma and tissue levels without consistently reducing endogenous production.

Meta-Analysis on Oxidative Stress (2020, Comprehensive Reviews in Food Science): Arenas-Jal et al. found that CoQ10 supplementation (100–300 mg/day) increases antioxidant capacity and reduces oxidative stress markers (e.g., malondialdehyde). The study implies that supplementation supports cellular function without disrupting endogenous CoQ10 synthesis, though it doesn’t directly measure production rates.

Frontiers | Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis

Introduction: Although several meta-analyses support the positive effect of coenzyme Q10 (CoQ10) on biomarkers of oxidative stress and inflammation, the resu...

www.frontiersin.org

https://ift.onlinelibrary.wiley.com/doi/abs/10.1111/1541-4337.12539

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges - PubMed

World population growth and aging are posing unprecedented challenges in sustaining the health of 9.1 billion people that will be occupying the planet by 2050. Although noncommunicable diseases such as cardiovascular and neurodegenerative diseases, cancer, and diabetes are among the top 10...

pubmed.ncbi.nlm.nih.gov

 

[Goldenpuncher]

Thanks!,;aYou seem tp know a lot, although if their was a diagram or study specifically showing Ubiquinone(coq10) production plain and simply not being reduced post erogenous use, that would be helpful, None the less I have a general idea people don't talk about feeling taken down a notch after Coq10 withdrawal sets in.